PDF(Pubmed)
Abstract：
UNASSIGNED: Skin defects caused by open hand trauma are difficult to treat clinically and severely affect the recovery of hand function. Autologous platelet-rich plasma (PRP) has been widely used in the treatment of refractory chronic wounds, but its use in hand trauma skin defects remains scarce.
UNASSIGNED: This study compared the outcomes of 27 patients treated with PRP to 31 patients undergoing skin flap transplantation for hand wounds. We assessed several parameters, including healing times, duration of surgery, postoperative pain (VAS score), intraoperative amputation length, finger function, sensation restoration, nail bed preservation, and hospitalization expenses.
UNASSIGNED: PRP-treated patients showed a mean healing time of 21.59 ± 3.17 days. Surgical times were significantly shorter in the PRP group (22.04 ± 7.04 min) compared to the flap group (57.45 ± 8.15 min, P < 0.0001). PRP patients experienced longer postoperative healing times (20.15 ± 2.16 days) than those in the skin flap group (12.84 ± 1.08 days, P < 0.0001), but reported lower pain scores (1.3 ± 1.44 vs 2.55 ± 2.06, P = 0.0119). Range of Motion (ROM) at the proximal interphalangeal joint was better in the PRP group (96.26° ± 6.69) compared to the flap group (86.16° ± 15.24, P = 0.0028). Sensory outcomes favored the PRP group, with a two-point discrimination of 2.37 ± 1.34 mm versus 2.52 ± 1.27 mm in the flap group (P = 0.0274). Costs were lower in the PRP group ($2081.6 ± 258.14 vs $2680.18 ± 481.15, P < 0.0001).
UNASSIGNED: PRP treatment for skin defects from hand trauma is effective, offering advantages in terms of reduced surgical time, pain, and cost, with comparable or superior functional outcomes to flap transplantation. Despite longer healing times, PRP may represent a preferable option for open hand injuries, preserving more nail beds and resulting in better sensation and joint motion.
UNASSIGNED: This study compared the outcomes of 27 patients treated with PRP to 31 patients undergoing skin flap transplantation for hand wounds. We assessed several parameters, including healing times, duration of surgery, postoperative pain (VAS score), intraoperative amputation length, finger function, sensation restoration, nail bed preservation, and hospitalization expenses.
UNASSIGNED: PRP-treated patients showed a mean healing time of 21.59 ± 3.17 days. Surgical times were significantly shorter in the PRP group (22.04 ± 7.04 min) compared to the flap group (57.45 ± 8.15 min, P < 0.0001). PRP patients experienced longer postoperative healing times (20.15 ± 2.16 days) than those in the skin flap group (12.84 ± 1.08 days, P < 0.0001), but reported lower pain scores (1.3 ± 1.44 vs 2.55 ± 2.06, P = 0.0119). Range of Motion (ROM) at the proximal interphalangeal joint was better in the PRP group (96.26° ± 6.69) compared to the flap group (86.16° ± 15.24, P = 0.0028). Sensory outcomes favored the PRP group, with a two-point discrimination of 2.37 ± 1.34 mm versus 2.52 ± 1.27 mm in the flap group (P = 0.0274). Costs were lower in the PRP group ($2081.6 ± 258.14 vs $2680.18 ± 481.15, P < 0.0001).
UNASSIGNED: PRP treatment for skin defects from hand trauma is effective, offering advantages in terms of reduced surgical time, pain, and cost, with comparable or superior functional outcomes to flap transplantation. Despite longer healing times, PRP may represent a preferable option for open hand injuries, preserving more nail beds and resulting in better sensation and joint motion.
摘要：
■开放性手外伤引起的皮肤缺损在临床上难以治疗，严重影响手功能的恢复。自体富血小板血浆(PRP)已广泛应用于难治性慢性伤口的治疗,但其在手外伤皮肤缺损中的应用仍然很少。
■本研究比较了27例接受PRP治疗的患者和31例接受皮瓣移植治疗手部伤口的患者的结果。我们评估了几个参数，包括治愈时间，手术持续时间,术后疼痛（VAS评分），术中截肢长度,手指功能,感觉恢复,甲床保存,和住院费用。
■PRP治疗的患者显示平均愈合时间为21.59±3.17天。手术时间PRP组(22.04±7.04min)明显短于皮瓣组(57.45±8.15min,P<0.0001)。PRP患者术后愈合时间(20.15±2.16天)长于皮瓣组(12.84±1.08天,P<0.0001),但报告疼痛评分较低(1.3±1.44vs2.55±2.06,P=0.0119)。PRP组（96.26°±6.69）的近端指间关节运动范围（ROM）优于皮瓣组（86.16°±15.24，P=0.0028）。感觉结果有利于PRP组，皮瓣组的两点判别为2.37±1.34mm，而皮瓣组为2.52±1.27mm（P=0.0274）。PRP组的费用较低（$2081.6±258.14vs$2680.18±481.15，P<0.0001）。
■PRP治疗手外伤皮肤缺损是有效的，在减少手术时间方面提供优势，疼痛,和成本，具有与皮瓣移植相当或更好的功能结果。尽管治疗时间更长，PRP可能是手部开放性损伤的首选方案，保留更多的甲床，并导致更好的感觉和关节运动。
■本研究比较了27例接受PRP治疗的患者和31例接受皮瓣移植治疗手部伤口的患者的结果。我们评估了几个参数，包括治愈时间，手术持续时间,术后疼痛（VAS评分），术中截肢长度,手指功能,感觉恢复,甲床保存,和住院费用。
■PRP治疗的患者显示平均愈合时间为21.59±3.17天。手术时间PRP组(22.04±7.04min)明显短于皮瓣组(57.45±8.15min,P<0.0001)。PRP患者术后愈合时间(20.15±2.16天)长于皮瓣组(12.84±1.08天,P<0.0001),但报告疼痛评分较低(1.3±1.44vs2.55±2.06,P=0.0119)。PRP组（96.26°±6.69）的近端指间关节运动范围（ROM）优于皮瓣组（86.16°±15.24，P=0.0028）。感觉结果有利于PRP组，皮瓣组的两点判别为2.37±1.34mm，而皮瓣组为2.52±1.27mm（P=0.0274）。PRP组的费用较低（$2081.6±258.14vs$2680.18±481.15，P<0.0001）。
■PRP治疗手外伤皮肤缺损是有效的，在减少手术时间方面提供优势，疼痛,和成本，具有与皮瓣移植相当或更好的功能结果。尽管治疗时间更长，PRP可能是手部开放性损伤的首选方案，保留更多的甲床，并导致更好的感觉和关节运动。
