PDF(Pubmed)
Abstract：
UNASSIGNED: Pregnancy serves as a physiological stress test for the thyroid which often leads to dysfunction in women with limited thyroid reserves. The occurrence of gestational thyroid dysfunction is linked to unfavourable obstetric and foetal outcomes. Globally, iodine deficiency is a prominent causative factor for thyroid dysfunction. The study aimed to determine the prevalence and pattern of thyroid dysfunction among pregnant women in Enugu, South-east Nigeria.
UNASSIGNED: This hospital-based descriptive cross-sectional and observational study was conducted over six months on selected participants from pregnant women attending antenatal clinics at the study sites. Maternal clinical and demographic risk factors for thyroid dysfunction were evaluated in a cohort of 318 pregnant women. An analysis of variance (ANOVA) was performed to compare participants\' thyroid status across different trimesters of pregnancy, and different thyroid and nutritional iodine states.
UNASSIGNED: The prevalence of thyroid dysfunction in the study population is 6.6%. Hypothyroidism was detected in 5.3% of the participants, consisting of 3.8% sub-clinical hypothyroidism and 1.6% overt hypothyroidism. Sub-clinical hyperthyroidism accounted for 1.3% of all participants; no overt hyperthyroidism was detected in this study.
UNASSIGNED: There is a relatively high prevalence of gestational thyroid dysfunction in the study population with hypothyroidism being the predominant disorder. This highlights the need for region-specific considerations in antenatal care to facilitate early detection and effective management of gestational thyroid dysfunction, thereby mitigating potential adverse maternal and foetal outcomes.
UNASSIGNED: This hospital-based descriptive cross-sectional and observational study was conducted over six months on selected participants from pregnant women attending antenatal clinics at the study sites. Maternal clinical and demographic risk factors for thyroid dysfunction were evaluated in a cohort of 318 pregnant women. An analysis of variance (ANOVA) was performed to compare participants\' thyroid status across different trimesters of pregnancy, and different thyroid and nutritional iodine states.
UNASSIGNED: The prevalence of thyroid dysfunction in the study population is 6.6%. Hypothyroidism was detected in 5.3% of the participants, consisting of 3.8% sub-clinical hypothyroidism and 1.6% overt hypothyroidism. Sub-clinical hyperthyroidism accounted for 1.3% of all participants; no overt hyperthyroidism was detected in this study.
UNASSIGNED: There is a relatively high prevalence of gestational thyroid dysfunction in the study population with hypothyroidism being the predominant disorder. This highlights the need for region-specific considerations in antenatal care to facilitate early detection and effective management of gestational thyroid dysfunction, thereby mitigating potential adverse maternal and foetal outcomes.
摘要：
妊娠是甲状腺的生理压力测试，通常会导致甲状腺储备有限的女性功能障碍。妊娠期甲状腺功能障碍的发生与不良的产科和胎儿结局有关。全球范围内,碘缺乏是甲状腺功能异常的主要原因。该研究旨在确定Enugu孕妇甲状腺功能障碍的患病率和模式，尼日利亚东南部。
这项基于医院的描述性横断面和观察性研究是在六个月内对在研究地点参加产前诊所的孕妇进行的。在318名孕妇的队列中评估了甲状腺功能障碍的孕妇临床和人口统计学危险因素。进行方差分析(ANOVA)以比较参与者在不同妊娠期间的甲状腺状态,和不同的甲状腺和营养碘状态。
■研究人群中甲状腺功能障碍的患病率为6.6%。在5.3％的参与者中检测到甲状腺功能减退，包括3.8%的亚临床甲状腺功能减退症和1.6%的明显甲状腺功能减退症。亚临床甲状腺功能亢进占所有参与者的1.3%；在这项研究中没有检测到明显的甲状腺功能亢进。
在研究人群中，妊娠甲状腺功能障碍的患病率相对较高，甲状腺功能减退是主要疾病。这突出了在产前护理中需要针对特定地区的考虑，以促进早期发现和有效管理妊娠期甲状腺功能障碍，从而减轻潜在的不良母婴结局。
这项基于医院的描述性横断面和观察性研究是在六个月内对在研究地点参加产前诊所的孕妇进行的。在318名孕妇的队列中评估了甲状腺功能障碍的孕妇临床和人口统计学危险因素。进行方差分析(ANOVA)以比较参与者在不同妊娠期间的甲状腺状态,和不同的甲状腺和营养碘状态。
■研究人群中甲状腺功能障碍的患病率为6.6%。在5.3％的参与者中检测到甲状腺功能减退，包括3.8%的亚临床甲状腺功能减退症和1.6%的明显甲状腺功能减退症。亚临床甲状腺功能亢进占所有参与者的1.3%；在这项研究中没有检测到明显的甲状腺功能亢进。
在研究人群中，妊娠甲状腺功能障碍的患病率相对较高，甲状腺功能减退是主要疾病。这突出了在产前护理中需要针对特定地区的考虑，以促进早期发现和有效管理妊娠期甲状腺功能障碍，从而减轻潜在的不良母婴结局。
