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Abstract：
Phyllodes tumors (PTs) of the breast are rare fibroepithelial neoplasms, typically characterized by their benign nature. We present a unique case of a 29-year-old Pakistani female who initially presented with a benign PT in her left breast. Despite undergoing multiple surgical resections over the course of a decade, the tumor exhibited a remarkable transformation in biology, progressing from a benign phenotype to malignancy. Subsequent recurrences manifested with increasing aggressiveness, ultimately culminating in distant metastasis to the bones, axillary nodes, chest wall, and abdominal wall. This case underscores the unpredictable nature of PTs and highlights the challenges in managing recurrent cases with malignant transformation. The clinical course described herein emphasizes the importance of vigilant monitoring and individualized treatment strategies in such cases.
摘要：
乳腺叶状肿瘤（PT）是罕见的纤维上皮肿瘤，通常以它们的良性性质为特征。我们介绍了一名29岁的巴基斯坦女性的独特病例，该女性最初在左乳房中出现良性PT。尽管在十年的时间里接受了多次手术切除，肿瘤在生物学上表现出显著的转变，从良性表型发展为恶性肿瘤。随后的复发表现为越来越积极，最终导致远处转移到骨骼，腋窝结节，胸壁,和腹壁。此病例强调了PT的不可预测性质，并强调了在处理具有恶性转化的复发性病例方面的挑战。本文描述的临床过程强调了在这种情况下警惕监测和个性化治疗策略的重要性。
