PDF(Pubmed)
Abstract：
UNASSIGNED: Bidirectional Mendelian randomization (MR) combined with clinical case analysis was used to elucidate the relationship between generalized anxiety disorder (GAD) caused by mental overload and the risk of weight-bearing joint (hip/knee) osteoarthritis (OA).
UNASSIGNED: We performed MR analyses using publicly released genome-wide association study summary statistics to measure the causal effects between mental overload and weight-bearing joint OA risk. The primary MR analysis utilized the inverse-variance weighted (IVW) method, complemented by additional methods, including simple mode, weighted mode, MR-Egger regression, and weighted median. The leave-one-out method was used for sensitivity analysis. Concurrently, data from patients with OA (Kellgren-Lawrence grades III-IV) who needed total knee/hip arthroplasty were collected. Patient assessments were conducted utilizing the Western Ontario and McMaster Universities arthritis index, Penn State worry questionnaire, and visual analogue scale.
UNASSIGNED: Genetically predisposed GAD did not correlate with the risk of weight-bearing joint OA (IVW odds ratio [OR] = 0.840, 95 % confidence interval = 0.128, 5.50, P = 0.855). In reverse MR analyses, we detected no causal effect of weight-bearing OA on GAD (IVW OR = 1.00, 95 % CI = 0.985, 1.03, P = 0.687). In the clinical case evaluation, weight overload joint OA and GAD were highly correlated.
UNASSIGNED: MR analysis indicated no bidirectional causal effect of GAD caused by mental overload on weight-bearing joint (hip or knee) OA. Clinical studies support the finding that GAD is highly correlated with weight-bearing joint OA. However, whether there is a causal relationship between GAD caused by mental overload and weight-overloading joint OA requires further investigation.
UNASSIGNED: We performed MR analyses using publicly released genome-wide association study summary statistics to measure the causal effects between mental overload and weight-bearing joint OA risk. The primary MR analysis utilized the inverse-variance weighted (IVW) method, complemented by additional methods, including simple mode, weighted mode, MR-Egger regression, and weighted median. The leave-one-out method was used for sensitivity analysis. Concurrently, data from patients with OA (Kellgren-Lawrence grades III-IV) who needed total knee/hip arthroplasty were collected. Patient assessments were conducted utilizing the Western Ontario and McMaster Universities arthritis index, Penn State worry questionnaire, and visual analogue scale.
UNASSIGNED: Genetically predisposed GAD did not correlate with the risk of weight-bearing joint OA (IVW odds ratio [OR] = 0.840, 95 % confidence interval = 0.128, 5.50, P = 0.855). In reverse MR analyses, we detected no causal effect of weight-bearing OA on GAD (IVW OR = 1.00, 95 % CI = 0.985, 1.03, P = 0.687). In the clinical case evaluation, weight overload joint OA and GAD were highly correlated.
UNASSIGNED: MR analysis indicated no bidirectional causal effect of GAD caused by mental overload on weight-bearing joint (hip or knee) OA. Clinical studies support the finding that GAD is highly correlated with weight-bearing joint OA. However, whether there is a causal relationship between GAD caused by mental overload and weight-overloading joint OA requires further investigation.
摘要：
■双向孟德尔随机化（MR）结合临床病例分析，阐明精神超负荷引起的广泛性焦虑障碍（GAD）与负重关节（髋/膝）骨关节炎（OA）风险之间的关系。
■我们使用公开发布的全基因组关联研究汇总统计数据进行了MR分析，以衡量精神超负荷和负重关节OA风险之间的因果关系。主要的MR分析使用逆方差加权(IVW)方法，辅以额外的方法，包括简单模式，加权模式，MR-Egger回归，和加权中位数。采用留一法进行敏感性分析。同时,我们收集了需要全膝/髋关节置换术的OA患者(Kellgren-LawrenceIII-IV级)的数据.患者评估利用西安大略省和麦克马斯特大学关节炎指数进行，宾夕法尼亚州立大学担忧问卷，和视觉模拟量表。
■遗传易感GAD与负重关节OA的风险无关（IVW比值比[OR]=0.840，95％置信区间=0.128，5.50，P=0.855）。在反向MR分析中，我们未检测到负重OA对GAD的因果效应(IVWOR=1.00,95%CI=0.985,1.03,P=0.687)。在临床病例评估中，体重超负荷关节OA与GAD高度相关。
■MR分析表明，精神超负荷对负重关节（髋或膝）OA无双向因果效应。临床研究支持GAD与负重关节OA高度相关的发现。然而,精神超负荷所致GAD与体重超负荷关节OA之间是否存在因果关系需要进一步调查.
■我们使用公开发布的全基因组关联研究汇总统计数据进行了MR分析，以衡量精神超负荷和负重关节OA风险之间的因果关系。主要的MR分析使用逆方差加权(IVW)方法，辅以额外的方法，包括简单模式，加权模式，MR-Egger回归，和加权中位数。采用留一法进行敏感性分析。同时,我们收集了需要全膝/髋关节置换术的OA患者(Kellgren-LawrenceIII-IV级)的数据.患者评估利用西安大略省和麦克马斯特大学关节炎指数进行，宾夕法尼亚州立大学担忧问卷，和视觉模拟量表。
■遗传易感GAD与负重关节OA的风险无关（IVW比值比[OR]=0.840，95％置信区间=0.128，5.50，P=0.855）。在反向MR分析中，我们未检测到负重OA对GAD的因果效应(IVWOR=1.00,95%CI=0.985,1.03,P=0.687)。在临床病例评估中，体重超负荷关节OA与GAD高度相关。
■MR分析表明，精神超负荷对负重关节（髋或膝）OA无双向因果效应。临床研究支持GAD与负重关节OA高度相关的发现。然而,精神超负荷所致GAD与体重超负荷关节OA之间是否存在因果关系需要进一步调查.
