PDF(Pubmed)
Abstract：
UNASSIGNED: There are many reports on the effects of trace elements on human anthropometric characteristics. Among these elements, cobalt has consistently shown an inverse relationship with obesity risk. In the present study, we aimed to investigate the relationship between urinary levels of trace elements, focusing on cobalt, and childhood obesity, as indicated by the body mass index (BMI) in early adolescents, focusing on the participants\' gender.
UNASSIGNED: A cross-sectional study was conducted in the Tokyo Teen Cohort study. Based on urinary samples, we obtained the anthropometric characteristics (weight and height) and potential covariates associated with childhood BMI for 1542 children (mean age=12 years; 860 boys and 682 girls).
UNASSIGNED: Concentrations of urinary cobalt and 17 other trace elements were measured using inductively coupled plasma-mass spectrometry or inductively coupled plasma-atomic emission spectrometry.
UNASSIGNED: Pearson\'s correlation coefficient revealed an inverse relationship between the log of cobalt concentrations in the urine and the BMI for the boys (r=-0.125, p<0.001) and girls (r=-0.082, p=0.033). Multivariate analysis, adjusted for various covariates, reconfirmed the correlation between urine cobalt and the childhood BMI, only in the boys (beta=-0.14, p<0.001).
UNASSIGNED: Among the 18 elements measured in the children\'s urine, cobalt may exhibit sufficient potency to decrease the risk of childhood obesity, particularly in boys. Future studies are required to clearly determine the magnitude of the effect and the underlying mechanism(s).
UNASSIGNED: A cross-sectional study was conducted in the Tokyo Teen Cohort study. Based on urinary samples, we obtained the anthropometric characteristics (weight and height) and potential covariates associated with childhood BMI for 1542 children (mean age=12 years; 860 boys and 682 girls).
UNASSIGNED: Concentrations of urinary cobalt and 17 other trace elements were measured using inductively coupled plasma-mass spectrometry or inductively coupled plasma-atomic emission spectrometry.
UNASSIGNED: Pearson\'s correlation coefficient revealed an inverse relationship between the log of cobalt concentrations in the urine and the BMI for the boys (r=-0.125, p<0.001) and girls (r=-0.082, p=0.033). Multivariate analysis, adjusted for various covariates, reconfirmed the correlation between urine cobalt and the childhood BMI, only in the boys (beta=-0.14, p<0.001).
UNASSIGNED: Among the 18 elements measured in the children\'s urine, cobalt may exhibit sufficient potency to decrease the risk of childhood obesity, particularly in boys. Future studies are required to clearly determine the magnitude of the effect and the underlying mechanism(s).
摘要：
■关于微量元素对人体测量特征的影响的报道很多。在这些元素中，钴一直显示出与肥胖风险成反比的关系。在本研究中,我们的目的是调查尿微量元素水平之间的关系，专注于钴，和儿童肥胖，如早期青少年的体重指数（BMI）所示，关注参与者的性别。
■在东京青少年队列研究中进行了一项横断面研究。根据尿液样本,我们获得了1542名儿童(平均年龄=12岁;860名男孩和682名女孩)的人体测量特征(体重和身高)和与儿童BMI相关的潜在协变量.
■使用电感耦合等离子体-质谱法或电感耦合等离子体-原子发射光谱法测定了尿中钴和17种其他微量元素的浓度。
■Pearson的相关系数显示，男孩（r=-0.125，p<0.001）和女孩（r=-0.082，p=0.033）尿液中钴浓度的对数与BMI之间呈负相关关系。多变量分析，针对各种协变量进行调整，再次证实了尿钴与儿童BMI之间的相关性，仅在男孩中（β=-0.14，p<0.001）。
■在儿童尿液中测量的18种元素中，钴可能表现出足够的效力，以降低儿童肥胖的风险，尤其是男孩。未来的研究需要明确确定影响的大小和潜在的机制。
■在东京青少年队列研究中进行了一项横断面研究。根据尿液样本,我们获得了1542名儿童(平均年龄=12岁;860名男孩和682名女孩)的人体测量特征(体重和身高)和与儿童BMI相关的潜在协变量.
■使用电感耦合等离子体-质谱法或电感耦合等离子体-原子发射光谱法测定了尿中钴和17种其他微量元素的浓度。
■Pearson的相关系数显示，男孩（r=-0.125，p<0.001）和女孩（r=-0.082，p=0.033）尿液中钴浓度的对数与BMI之间呈负相关关系。多变量分析，针对各种协变量进行调整，再次证实了尿钴与儿童BMI之间的相关性，仅在男孩中（β=-0.14，p<0.001）。
■在儿童尿液中测量的18种元素中，钴可能表现出足够的效力，以降低儿童肥胖的风险，尤其是男孩。未来的研究需要明确确定影响的大小和潜在的机制。
