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Abstract：
OBJECTIVE: To evaluate the correlation between left atrial stiffness index (LASI) and left ventricular diastolic function in patients with coronary heart disease (CHD) by Autostrain LA technique.
METHODS: This was a retrospective analysis that included a total of 82 CHD patients who had suitable image quality for left atrial strain measurement. According to the 2016 ASE/EACVI guidelines for the echocardiographic assessment of diastolic dysfunction, the patients were divided into three groups: normal left ventricular diastolic function group (n = 26), indeterminate left ventricular diastolic function (n = 36), and left ventricular diastolic dysfunction (LVDD) (n = 20). The left atrial conduit strain (LAScd), Left atrial contractile strain (LASct), left atrial reservoir strain (LASr) and its derived parameters, including LASI and left atrial filling index (LAFI), were compared among the three groups. Furthermore, we conduct a correlation analysis between LASI and left ventricular diastolic function in patients with CHD.
RESULTS: LASr and LAScd in normal group were higher than those in indeterminate group, LASr and LAScd in indeterminate group were higher than those in LVDD group, LASI in normal group was lower than that in indeterminate group, and LASI in indeterminate group was lower than that in LVDD group (P < 0.001). LASct in both normal and indeterminate groups was higher than that in LVDD group (P < 0.05). The LAFI of normal group was lower than that of indeterminate group and LVDD group (P < 0.001). LASI was positively correlated with E/e\'(r = 0.822) (P < 0.001). LASr and E/e\' were negatively correlated (r = -0.637) (P < 0.001).
CONCLUSIONS: LASI is closely related to the changes of left ventricular diastolic function in CHD patients.
METHODS: This was a retrospective analysis that included a total of 82 CHD patients who had suitable image quality for left atrial strain measurement. According to the 2016 ASE/EACVI guidelines for the echocardiographic assessment of diastolic dysfunction, the patients were divided into three groups: normal left ventricular diastolic function group (n = 26), indeterminate left ventricular diastolic function (n = 36), and left ventricular diastolic dysfunction (LVDD) (n = 20). The left atrial conduit strain (LAScd), Left atrial contractile strain (LASct), left atrial reservoir strain (LASr) and its derived parameters, including LASI and left atrial filling index (LAFI), were compared among the three groups. Furthermore, we conduct a correlation analysis between LASI and left ventricular diastolic function in patients with CHD.
RESULTS: LASr and LAScd in normal group were higher than those in indeterminate group, LASr and LAScd in indeterminate group were higher than those in LVDD group, LASI in normal group was lower than that in indeterminate group, and LASI in indeterminate group was lower than that in LVDD group (P < 0.001). LASct in both normal and indeterminate groups was higher than that in LVDD group (P < 0.05). The LAFI of normal group was lower than that of indeterminate group and LVDD group (P < 0.001). LASI was positively correlated with E/e\'(r = 0.822) (P < 0.001). LASr and E/e\' were negatively correlated (r = -0.637) (P < 0.001).
CONCLUSIONS: LASI is closely related to the changes of left ventricular diastolic function in CHD patients.
摘要：
目的：应用自拟LA技术评价冠心病患者左心房僵硬度指数(LASI)与左心室舒张功能的相关性。
方法：这是一项回顾性分析，共纳入82例CHD患者，这些患者具有适合左心房应变测量的图像质量。根据2016年ASE/EACVI心脏超声心动图评估舒张功能障碍指南，将患者分为3组:左心室舒张功能正常组(n=26),左心室舒张功能不确定(n=36)，和左心室舒张功能障碍（LVDD）（n=20）。左心房导管应变(LAScd),左心房收缩劳损(LASct),左心房储层应变(LASr)及其导出参数，包括LASI和左心房充盈指数（LAFI），在三组之间进行比较。此外，我们进行LASI与CHD患者左心室舒张功能的相关性分析。
结果：正常组LASr和LAScd高于不确定组，不确定组LASr和LAScd高于LVDD组，正常组LASI低于不确定组，不确定组LASI低于LVDD组(P<0.001)。正常组和不确定组的LASct均高于LVDD组（P<0.05）。正常组LAFI低于不确定组和LVDD组（P<0.001）。LASI与E/e'呈正相关(r=0.822)(P<0.001)。LASr与E/e'呈负相关(r=-0.637)(P<0.001)。
结论：LASI与冠心病患者左心室舒张功能的改变密切相关。
方法：这是一项回顾性分析，共纳入82例CHD患者，这些患者具有适合左心房应变测量的图像质量。根据2016年ASE/EACVI心脏超声心动图评估舒张功能障碍指南，将患者分为3组:左心室舒张功能正常组(n=26),左心室舒张功能不确定(n=36)，和左心室舒张功能障碍（LVDD）（n=20）。左心房导管应变(LAScd),左心房收缩劳损(LASct),左心房储层应变(LASr)及其导出参数，包括LASI和左心房充盈指数（LAFI），在三组之间进行比较。此外，我们进行LASI与CHD患者左心室舒张功能的相关性分析。
结果：正常组LASr和LAScd高于不确定组，不确定组LASr和LAScd高于LVDD组，正常组LASI低于不确定组，不确定组LASI低于LVDD组(P<0.001)。正常组和不确定组的LASct均高于LVDD组（P<0.05）。正常组LAFI低于不确定组和LVDD组（P<0.001）。LASI与E/e'呈正相关(r=0.822)(P<0.001)。LASr与E/e'呈负相关(r=-0.637)(P<0.001)。
结论：LASI与冠心病患者左心室舒张功能的改变密切相关。
