Abstract：
Magnesium (Mg2+) is a commonly used dietary supplement for the prevention and treatment of diseases. However, the efficacy and mechanisms of action of Mg2+ in most diseases have been controversial because of conflicting findings in earlier studies. Recent clinical and preclinical studies provide novel insights into the use of Mg2+ for the treatment and prevention of diseases affecting different organ systems. In this review, we provide an overview of recent clinical evidence for, and controversies over, the medical benefits of Mg2+. In addition, we critically discuss recent advances in understanding the mechanisms of action of Mg2+, which could enable the development of novel targeted therapies.
摘要：
镁（Mg2+）是一种常用的膳食补充剂，用于预防和治疗疾病。然而,由于早期研究的结果相互矛盾,Mg2+在大多数疾病中的功效和作用机制一直存在争议.最近的临床和临床前研究提供了使用Mg2+治疗和预防影响不同器官系统的疾病的新见解。在这次审查中,我们概述了最近的临床证据，和争议，Mg2+的医疗益处。此外,我们批判性地讨论了在理解Mg2+作用机制方面的最新进展，这可能有助于开发新的靶向疗法。
