Abstract：
Objective Abstaining from alcohol improves the outcome of alcohol-related cirrhosis. This study evaluated the effect of alcohol abstinence on the outcomes of patients with alcohol-related cirrhosis recruited from a core hospital in Boso Peninsula, Japan. Methods This single-center retrospective study recruited 116 patients with alcohol-related cirrhosis who were admitted to our department between April 2014 and October 2022. Taking the day of discharge as day 0, the patients were divided into two groups based on their subsequent behavior (abstinence/non-abstinence from alcohol). The study analysis included 98 patients after excluding 13 who died during hospitalization and 5 for whom follow-up at our hospital ended after discharge. We evaluated differences in the patient survival between the abstaining and drinking groups. Results The abstaining and drinking groups comprised 57 and 41 patients, respectively. We excluded from the analysis 10 and 6 patients with viable hepatocellular carcinoma in the abstaining and drinking groups, respectively. The findings revealed that the survival rate plateaued in the abstaining group from the third year onward, whereas the survival rate in the drinking group gradually decreased with time. Conclusion Our findings suggest that at least two years of alcohol abstinence is required to sustain the survival of patients with alcohol-related cirrhosis. The data collected by our hospital retrospectively demonstrated the importance of abstinence on a timescale of years of sustained abstinence.
摘要：
目的戒酒可改善酒精相关性肝硬化的预后。这项研究评估了戒酒对从Boso半岛一家核心医院招募的酒精相关性肝硬化患者的预后的影响。日本。方法这项单中心回顾性研究纳入了2014年4月至2022年10月我科收治的116例酒精相关性肝硬化患者。以出院当天为第0天，根据患者随后的行为（戒酒/不戒酒）将患者分为两组。研究分析包括98名患者，其中13名患者在住院期间死亡，5名患者在出院后在我们医院结束随访。我们评估了弃权组和饮酒组之间患者生存率的差异。结果戒酒组57例,饮酒组41例,分别。我们从分析中排除了10例和6例可行的肝细胞癌患者，分别。研究结果表明，弃权组的生存率从第三年开始稳定，而饮酒组的存活率随时间逐渐降低。结论我们的研究结果表明，至少需要两年的戒酒才能维持酒精相关性肝硬化患者的生存。我们医院收集的数据回顾性地证明了在持续禁欲多年的时间尺度上禁欲的重要性。
