Abstract：
The notion that obesity can be a protective factor for bone health is a topic of ongoing debate. Increased body weight may have a positive impact on bone health due to its mechanical effects and the production of estrogen by adipose tissue. However, recent studies have found a higher risk of bone fracture and delayed bone healing in elderly obese patients, which may be attributed to the heightened risk of bone immune regulation disruption associated with obesity. The balanced functions of bone cells such as osteoclasts, osteoblasts, and osteocytes, would be subverted by aberrant and prolonged immune responses under obese conditions. This review aims to explore the intricate relationship between obesity and bone health from the perspective of osteoimmunology, elucidate the impact of disturbances in bone immune regulation on the functioning of bone cells, including osteoclasts, osteoblasts, and osteocytes, highlighting the deleterious effects of obesity on various diseases development such as rheumatoid arthritis (RA), osteoarthritis (AS), bone fracture, periodontitis. On the one hand, weight loss may achieve significant therapeutic effects on the aforementioned diseases. On the other hand, for patients who have difficulty in losing weight, the osteoimmunological therapies could potentially serve as a viable approach in halting the progression of these disease. Additional research in the field of osteoimmunology is necessary to ascertain the optimal equilibrium between body weight and bone health.
摘要：
肥胖可以成为骨骼健康保护因素的观点是一个正在进行辩论的话题。由于其机械作用和脂肪组织产生雌激素，体重增加可能对骨骼健康产生积极影响。然而,最近的研究发现，老年肥胖患者骨折和骨愈合延迟的风险更高，这可能归因于与肥胖相关的骨免疫调节破坏的风险增加。骨细胞如破骨细胞的平衡功能，成骨细胞，和骨细胞，在肥胖的情况下，会被异常和长期的免疫反应所颠覆。本文旨在从骨免疫学的角度探讨肥胖与骨骼健康之间的复杂关系。阐明骨免疫调节紊乱对骨细胞功能的影响，包括破骨细胞,成骨细胞，和骨细胞，强调肥胖对各种疾病发展的有害影响，如类风湿性关节炎（RA），骨关节炎（AS），骨折,牙周炎.一方面,减肥对上述疾病有显著的治疗效果。另一方面,对于减肥有困难的患者，骨免疫疗法有可能成为阻止这些疾病进展的可行方法.在骨免疫学领域的其他研究是必要的，以确定体重和骨骼健康之间的最佳平衡。
