Abstract：
Bacteriophages, which are viral predators of bacteria, have evolved to efficiently recognize, bind, infect, and lyse their host, resulting in the release of tens to hundreds of propagated viruses. These abilities have attracted biosensor developers who have developed new methods to detect bacteria. Recently, several comprehensive reviews have covered many of the advances made regarding the performance of phage-based biosensors. Therefore, in this review, we first describe the landscape of phage-based biosensors and then cover advances in other aspects of phage biology and engineering that can be used to make high-impact contributions to biosensor development. Many of these advances are in fields adjacent to analytical chemistry such as synthetic biology, machine learning, and genetic engineering and will allow those looking to develop phage-based biosensors to start taking alternative approaches, such as a bottom-up design and synthesis of custom phages with the singular task of detecting their host.
摘要：
噬菌体,它们是细菌的病毒捕食者，已经进化到有效地识别，绑定,感染，并lyse他们的主人，导致数十到数百种传播病毒的释放。这些能力吸引了生物传感器开发人员，他们开发了检测细菌的新方法。最近,一些全面的综述涵盖了关于基于噬菌体的生物传感器性能的许多进展。因此,在这次审查中,我们首先描述了基于噬菌体的生物传感器的前景，然后涵盖了噬菌体生物学和工程的其他方面的进展，这些进展可用于对生物传感器的开发做出高影响力的贡献。这些进展中的许多都是在与分析化学相邻的领域，如合成生物学，机器学习,和基因工程，并将允许那些寻求开发基于噬菌体的生物传感器的人开始采取替代方法，例如自下而上的设计和定制噬菌体的合成，具有检测其宿主的独特任务。
