Abstract：
OBJECTIVE: The study aimed to estimate the prevalence of HLA-B51 and HLA-B52 in Lebanese patients with spondyloarthritis (SpA) compared to healthy controls (HC). We further aimed to evaluate the impact of HLA-B51 on phenotype and identify the distribution of the alleles in the HLA-B locus.
METHODS: A case-control study enrolled consecutive SpA patients from three rheumatology clinics in Lebanon, including axial (axSpA), peripheral SpA (pSpA), and psoriatic arthritis (PsA) and HC from blood donors. Demographic and disease data were collected through interviews and file reviews, with testing of the entire HLA-B locus using molecular techniques. The prevalence of HLA-B51 and B52 was estimated in SpA patients versus controls. Prevalence comparisons were made, and logistic regression identified factors associated with HLA-B51 in patients.
RESULTS: Data from 120 HC and 86 SpA patients (65 axSpA, 15 pSpA, 6 PsA), mean age 25.6 and 46.4 years, respectively, showed a higher HLA-B51 prevalence in SpA (25.6%), especially axSpA (29.2%) versus HC (12.5%), p = 0.016, and a numerically higher HLA-B52 prevalence (8.1% versus 4.2%, p = 0.230). HLA-B51 correlated with recurrent oral ulcerations (OR 7.99(95%CI 2.14-29.84) and radiographic juxta-articular erosions (OR 7.65(95%CI 1.14-38.03)). HLA-B35 was the most dominant allele in both groups (18.7%), followed by HLA-B27 (15.7%) and HLA-B51 (13.4%) in SpA.
CONCLUSIONS: HLA-B51 was identified more frequently in patients with SpA compared to HC and was associated with recurrent oral ulcerations and juxta-articular radiographic erosions. Longitudinal studies are needed to determine whether this association indicates a disease overlap or might correlate with a specific SpA phenotype.
METHODS: A case-control study enrolled consecutive SpA patients from three rheumatology clinics in Lebanon, including axial (axSpA), peripheral SpA (pSpA), and psoriatic arthritis (PsA) and HC from blood donors. Demographic and disease data were collected through interviews and file reviews, with testing of the entire HLA-B locus using molecular techniques. The prevalence of HLA-B51 and B52 was estimated in SpA patients versus controls. Prevalence comparisons were made, and logistic regression identified factors associated with HLA-B51 in patients.
RESULTS: Data from 120 HC and 86 SpA patients (65 axSpA, 15 pSpA, 6 PsA), mean age 25.6 and 46.4 years, respectively, showed a higher HLA-B51 prevalence in SpA (25.6%), especially axSpA (29.2%) versus HC (12.5%), p = 0.016, and a numerically higher HLA-B52 prevalence (8.1% versus 4.2%, p = 0.230). HLA-B51 correlated with recurrent oral ulcerations (OR 7.99(95%CI 2.14-29.84) and radiographic juxta-articular erosions (OR 7.65(95%CI 1.14-38.03)). HLA-B35 was the most dominant allele in both groups (18.7%), followed by HLA-B27 (15.7%) and HLA-B51 (13.4%) in SpA.
CONCLUSIONS: HLA-B51 was identified more frequently in patients with SpA compared to HC and was associated with recurrent oral ulcerations and juxta-articular radiographic erosions. Longitudinal studies are needed to determine whether this association indicates a disease overlap or might correlate with a specific SpA phenotype.
摘要：
目的：该研究旨在评估黎巴嫩脊柱关节炎（SpA）患者与健康对照组（HC）相比，HLA-B51和HLA-B52的患病率。我们进一步旨在评估HLA-B51对表型的影响并鉴定HLA-B基因座中等位基因的分布。
方法：一项病例对照研究纳入了黎巴嫩三个风湿病诊所的连续SpA患者，包括轴向(axSpA)，外围SpA(pSpA),以及来自献血者的银屑病关节炎（PsA）和HC。通过访谈和文件审查收集了人口和疾病数据，使用分子技术检测整个HLA-B基因座。HLA-B51和B52的患病率在SpA患者和对照组中估计。进行了患病率比较，和logistic回归确定了患者中与HLA-B51相关的因素。
结果：来自120例HC和86例SpA患者的数据（65axSpA，15pSpA,6PsA），平均年龄25.6岁和46.4岁，分别,在SpA中显示出更高的HLA-B51患病率（25.6％），尤其是axSpA（29.2%）与HC（12.5%），p=0.016，HLA-B52患病率在数值上较高(8.1%对4.2%，p=0.230）。HLA-B51与复发性口腔溃疡相关（OR7.99（95CI2.14-29.84）和放射学近关节糜烂（OR7.65（95CI1.14-38.03））。HLA-B35是两组中最主要的等位基因（18.7％），其次是HLA-B27（15.7%）和HLA-B51（13.4%）。
结论：与HC相比，HLA-B51在SpA患者中更常见，并且与复发性口腔溃疡和近关节X线侵蚀有关。需要纵向研究来确定这种关联是否表明疾病重叠或可能与特定的SpA表型相关。
方法：一项病例对照研究纳入了黎巴嫩三个风湿病诊所的连续SpA患者，包括轴向(axSpA)，外围SpA(pSpA),以及来自献血者的银屑病关节炎（PsA）和HC。通过访谈和文件审查收集了人口和疾病数据，使用分子技术检测整个HLA-B基因座。HLA-B51和B52的患病率在SpA患者和对照组中估计。进行了患病率比较，和logistic回归确定了患者中与HLA-B51相关的因素。
结果：来自120例HC和86例SpA患者的数据（65axSpA，15pSpA,6PsA），平均年龄25.6岁和46.4岁，分别,在SpA中显示出更高的HLA-B51患病率（25.6％），尤其是axSpA（29.2%）与HC（12.5%），p=0.016，HLA-B52患病率在数值上较高(8.1%对4.2%，p=0.230）。HLA-B51与复发性口腔溃疡相关（OR7.99（95CI2.14-29.84）和放射学近关节糜烂（OR7.65（95CI1.14-38.03））。HLA-B35是两组中最主要的等位基因（18.7％），其次是HLA-B27（15.7%）和HLA-B51（13.4%）。
结论：与HC相比，HLA-B51在SpA患者中更常见，并且与复发性口腔溃疡和近关节X线侵蚀有关。需要纵向研究来确定这种关联是否表明疾病重叠或可能与特定的SpA表型相关。
