Abstract：
OBJECTIVE: The aim of the present review was to highlight natural product investigations in silico and in vitro to find plants and chemicals that inhibit or stimulate angiotensin-converting enzyme 2 (ACE-2).
BACKGROUND: The global reduction of incidents and fatalities attributable to infections with SARS-CoV-2 is one of the most public health problems. In the absence of specific therapy for coronavirus disease 2019 (COVID-19), phytocompounds generated from plant extracts may be a promising strategy worth further investigation, motivating researchers to evaluate the safety and anti-SARS-CoV-2 effectiveness of these ingredients.
OBJECTIVE: To review phytochemicals in silico for anti-SARS-CoV-2 activity and to assess their safety and effectiveness in vitro and in vivo.
METHODS: The present review was conducted using various scientific databases and studies on anti-SARS-CoV-2 phytochemicals were analyzed and summarized. The results obtained from the in silico screening were subjected to extraction, isolation, and purification. The in vitro studies on anti-SarcoV-2 were also included in this review. In addition, the results of this research were interpreted, analyzed, and documented on the basis of the bibliographic information obtained.
RESULTS: This review discusses recent research on using natural remedies to cure or prevent COVID-19 infection. The literature analysis shows that the various herbal preparations (extracts) and purified compounds can block the replication or entrance of the virus directly to carry out their anti-SARS-CoV-2 effects. It is interesting to note that certain items can prevent SARS-CoV-2 from infecting human cells by blocking the ACE-2 receptor or the serine protease TMPRRS2. Moreover, natural substances have been demonstrated to block proteins involved in the SARS-CoV-2 life cycle, such as papain- or chymotrypsin-like proteases.
CONCLUSIONS: The natural products may have the potential for use singly or in combination as alternative drugs to treat/prevent COVID-19 infection, including blocking or stimulating ACE-2. In addition, their structures may provide indications for the development of anti-SARS-CoV-2 drugs.
BACKGROUND: The global reduction of incidents and fatalities attributable to infections with SARS-CoV-2 is one of the most public health problems. In the absence of specific therapy for coronavirus disease 2019 (COVID-19), phytocompounds generated from plant extracts may be a promising strategy worth further investigation, motivating researchers to evaluate the safety and anti-SARS-CoV-2 effectiveness of these ingredients.
OBJECTIVE: To review phytochemicals in silico for anti-SARS-CoV-2 activity and to assess their safety and effectiveness in vitro and in vivo.
METHODS: The present review was conducted using various scientific databases and studies on anti-SARS-CoV-2 phytochemicals were analyzed and summarized. The results obtained from the in silico screening were subjected to extraction, isolation, and purification. The in vitro studies on anti-SarcoV-2 were also included in this review. In addition, the results of this research were interpreted, analyzed, and documented on the basis of the bibliographic information obtained.
RESULTS: This review discusses recent research on using natural remedies to cure or prevent COVID-19 infection. The literature analysis shows that the various herbal preparations (extracts) and purified compounds can block the replication or entrance of the virus directly to carry out their anti-SARS-CoV-2 effects. It is interesting to note that certain items can prevent SARS-CoV-2 from infecting human cells by blocking the ACE-2 receptor or the serine protease TMPRRS2. Moreover, natural substances have been demonstrated to block proteins involved in the SARS-CoV-2 life cycle, such as papain- or chymotrypsin-like proteases.
CONCLUSIONS: The natural products may have the potential for use singly or in combination as alternative drugs to treat/prevent COVID-19 infection, including blocking or stimulating ACE-2. In addition, their structures may provide indications for the development of anti-SARS-CoV-2 drugs.
摘要：
目的：本综述的目的是强调在计算机和体外的天然产物研究，以寻找抑制或刺激血管紧张素转换酶2（ACE-2）的植物和化学物质。
背景：SARS-CoV-2感染引起的事件和死亡的全球减少是最公共的健康问题之一。在缺乏2019年冠状病毒病(COVID-19)的特异性治疗的情况下，从植物提取物中产生的植物化合物可能是值得进一步研究的有希望的策略，激励研究人员评估这些成分的安全性和抗SARS-CoV-2有效性。
目的：评价植物化学物抗SARS-CoV-2活性，并评估其体外和体内的安全性和有效性。
方法：本综述是使用各种科学数据库进行的，并对抗SARS-CoV-2植物化学物质的研究进行了分析和总结。将从计算机筛选中获得的结果进行提取，隔离,和净化。本综述还包括抗SarcoV-2的体外研究。此外,对这项研究的结果进行了解释，分析,并根据获得的书目信息进行记录。
结果：本综述讨论了使用自然疗法治疗或预防COVID-19感染的最新研究。文献分析表明，各种草药制剂（提取物）和纯化化合物可以直接阻断病毒的复制或进入，从而发挥其抗SARS-CoV-2作用。有趣的是，某些项目可以通过阻断ACE-2受体或丝氨酸蛋白酶TMPRRS2来防止SARS-CoV-2感染人细胞。此外，天然物质已被证明可以阻断参与SARS-CoV-2生命周期的蛋白质，如木瓜蛋白酶或胰凝乳蛋白酶样蛋白酶。
结论：天然产物可能具有单独或联合用作治疗/预防COVID-19感染的替代药物的潜力，包括阻断或刺激ACE-2。此外,它们的结构可能为抗SARS-CoV-2药物的开发提供适应症。
背景：SARS-CoV-2感染引起的事件和死亡的全球减少是最公共的健康问题之一。在缺乏2019年冠状病毒病(COVID-19)的特异性治疗的情况下，从植物提取物中产生的植物化合物可能是值得进一步研究的有希望的策略，激励研究人员评估这些成分的安全性和抗SARS-CoV-2有效性。
目的：评价植物化学物抗SARS-CoV-2活性，并评估其体外和体内的安全性和有效性。
方法：本综述是使用各种科学数据库进行的，并对抗SARS-CoV-2植物化学物质的研究进行了分析和总结。将从计算机筛选中获得的结果进行提取，隔离,和净化。本综述还包括抗SarcoV-2的体外研究。此外,对这项研究的结果进行了解释，分析,并根据获得的书目信息进行记录。
结果：本综述讨论了使用自然疗法治疗或预防COVID-19感染的最新研究。文献分析表明，各种草药制剂（提取物）和纯化化合物可以直接阻断病毒的复制或进入，从而发挥其抗SARS-CoV-2作用。有趣的是，某些项目可以通过阻断ACE-2受体或丝氨酸蛋白酶TMPRRS2来防止SARS-CoV-2感染人细胞。此外，天然物质已被证明可以阻断参与SARS-CoV-2生命周期的蛋白质，如木瓜蛋白酶或胰凝乳蛋白酶样蛋白酶。
结论：天然产物可能具有单独或联合用作治疗/预防COVID-19感染的替代药物的潜力，包括阻断或刺激ACE-2。此外,它们的结构可能为抗SARS-CoV-2药物的开发提供适应症。
