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Abstract：
BACKGROUND: Dual-phase fluorine-18 labeled N-3-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (18F-FP-CIT) positron emission tomography (PET) scans could be used to support disorders like Parkinson\'s disease (PD). Dopamine transporter (DAT) binding and cerebral perfusion are associated with ageing and gender. We investigated the effects of age and gender on non-degenerative parkinsonism, using automated quantification in striatum: specific binding ratios (SBRs) for DAT binding in delayed phase PET (dCIT) and standardized-uptake-value ratios (SUVRs) for cerebral perfusion in early phase PET (eCIT). We also examined the correlations between SBR and SUVR.
METHODS: This retrospective study analyzed subjects with dual-phase 18F-FP-CIT PET scans. The eCIT images were acquired immediately post-injection, and dCIT images were taken 120 min later. With Brightonix software, automated quantification of SBRs for dCIT and SUVRs for eCIT were acquired from visually normal scans. The effects of aging and gender were assessed by regressing SBRs and SUVRs on age for both genders. The correlations between SUVRs and SBRs were evaluated.
RESULTS: We studied 79 subjects (34 males and 45 females). An age-related reduction in SBRs was observed in the dorsal striatum, ventral striatum, caudate nucleus, and putamen for both genders. SUVRs were found to negatively correlate with age in the dorsal striatum, ventral striatum, caudate nucleus, and putamen for males and in the dorsal striatum and caudate nucleus for females. Positive correlations between SBRs and SUVRs in the dorsal striatum, ventral striatum, caudate nucleus, and putamen for male and in the dorsal striatum, caudate nucleus, and putamen for females.
CONCLUSIONS: Using quantified values from dual-phase 18F-FP-CIT PET with a single injection, we demonstrate a negative impact of age on SBRs (DAT binding) in the striatum for both genders and SUVRs (cerebral perfusion) in the dorsal striatum and caudate nucleus for both genders and in the ventral striatum and putamen for males. Additionally, we found positive associations between SBR and SUVR values in the dorsal striatum, caudate nucleus, and putamen for both genders and in the ventral striatum for males.
METHODS: This retrospective study analyzed subjects with dual-phase 18F-FP-CIT PET scans. The eCIT images were acquired immediately post-injection, and dCIT images were taken 120 min later. With Brightonix software, automated quantification of SBRs for dCIT and SUVRs for eCIT were acquired from visually normal scans. The effects of aging and gender were assessed by regressing SBRs and SUVRs on age for both genders. The correlations between SUVRs and SBRs were evaluated.
RESULTS: We studied 79 subjects (34 males and 45 females). An age-related reduction in SBRs was observed in the dorsal striatum, ventral striatum, caudate nucleus, and putamen for both genders. SUVRs were found to negatively correlate with age in the dorsal striatum, ventral striatum, caudate nucleus, and putamen for males and in the dorsal striatum and caudate nucleus for females. Positive correlations between SBRs and SUVRs in the dorsal striatum, ventral striatum, caudate nucleus, and putamen for male and in the dorsal striatum, caudate nucleus, and putamen for females.
CONCLUSIONS: Using quantified values from dual-phase 18F-FP-CIT PET with a single injection, we demonstrate a negative impact of age on SBRs (DAT binding) in the striatum for both genders and SUVRs (cerebral perfusion) in the dorsal striatum and caudate nucleus for both genders and in the ventral striatum and putamen for males. Additionally, we found positive associations between SBR and SUVR values in the dorsal striatum, caudate nucleus, and putamen for both genders and in the ventral striatum for males.
摘要：
背景：双相氟-18标记的N-3-氟丙基-2β-甲氧甲氧基-3β-（4-碘苯基）去甲托烷（18F-FP-CIT）正电子发射断层扫描（PET）扫描可用于支持帕金森病（PD）等疾病。多巴胺转运体（DAT）结合和脑灌注与衰老和性别有关。我们调查了年龄和性别对非退行性帕金森病的影响，使用纹状体自动定量：延迟期PET（dCIT）中DAT结合的特异性结合比（SBR）和早期PET（eCIT）中脑灌注的标准化摄取值比（SUVR）。我们还研究了SBR和SUVR之间的相关性。
方法：这项回顾性研究分析了受试者的18F-FP-CIT双阶段PET扫描。注射后立即获取eCIT图像，120分钟后拍摄dCIT图像。有了Brightonix软件,从视觉正常扫描获得dCIT的SBR和eCIT的SUVR的自动定量.通过回归两种性别的SBR和SUVR对年龄的影响来评估衰老和性别的影响。评估SUVR和SBR之间的相关性。
结果：我们研究了79名受试者（34名男性和45名女性）。在背侧纹状体中观察到与年龄相关的SBR减少，腹侧纹状体,尾状核,和两种性别的壳核。发现SUVR与背侧纹状体的年龄呈负相关，腹侧纹状体,尾状核,雄性和壳核，雌性在背侧纹状体和尾状核中。背侧纹状体SBR与SUVR呈正相关，腹侧纹状体,尾状核,男性和背侧纹状体的壳核，尾状核,女性的壳核。
结论：使用单次注射的双相18F-FP-CITPET的定量值，我们证明了年龄对性别的纹状体中的SBR(DAT结合)以及性别的背侧纹状体和尾状核以及男性的腹侧纹状体和壳核的SUVRs(脑灌注)都有负面影响.此外,我们发现背部纹状体SBR和SUVR值之间存在正相关，尾状核,性别和男性腹侧纹状体中的壳核。
方法：这项回顾性研究分析了受试者的18F-FP-CIT双阶段PET扫描。注射后立即获取eCIT图像，120分钟后拍摄dCIT图像。有了Brightonix软件,从视觉正常扫描获得dCIT的SBR和eCIT的SUVR的自动定量.通过回归两种性别的SBR和SUVR对年龄的影响来评估衰老和性别的影响。评估SUVR和SBR之间的相关性。
结果：我们研究了79名受试者（34名男性和45名女性）。在背侧纹状体中观察到与年龄相关的SBR减少，腹侧纹状体,尾状核,和两种性别的壳核。发现SUVR与背侧纹状体的年龄呈负相关，腹侧纹状体,尾状核,雄性和壳核，雌性在背侧纹状体和尾状核中。背侧纹状体SBR与SUVR呈正相关，腹侧纹状体,尾状核,男性和背侧纹状体的壳核，尾状核,女性的壳核。
结论：使用单次注射的双相18F-FP-CITPET的定量值，我们证明了年龄对性别的纹状体中的SBR(DAT结合)以及性别的背侧纹状体和尾状核以及男性的腹侧纹状体和壳核的SUVRs(脑灌注)都有负面影响.此外,我们发现背部纹状体SBR和SUVR值之间存在正相关，尾状核,性别和男性腹侧纹状体中的壳核。
