Abstract：
G protein-coupled receptors (GPCRs) are essential contributors to tumor growth and metastasis due to their roles in immune cell regulation. Therefore, GPCRs are potential targets for cancer immunotherapy. Here, we discuss the current understanding of the roles of GPCRs and their signaling pathways in tumor progression from an immunocellular perspective. Additionally, we focus on the roles of GPCRs in regulating immune checkpoint proteins involved in immune evasion. Finally, we review the progress of clinical trials of GPCR-targeted drugs for cancer treatment, which may be combined with immunotherapy to improve treatment efficacy. This expanded understanding of the role of GPCRs may shed light on the mechanisms underlying tumor progression and provide a novel perspective on cancer immunotherapy.
摘要：
G蛋白偶联受体（GPCRs）是肿瘤生长和转移的重要贡献者，因为它们在免疫细胞调节中的作用。因此,GPCRs是癌症免疫治疗的潜在靶标。这里,我们从免疫细胞的角度讨论了目前对GPCRs及其信号通路在肿瘤进展中作用的认识.此外,我们关注GPCRs在调节参与免疫逃避的免疫检查点蛋白中的作用.最后,我们综述了GPCR靶向药物治疗癌症的临床试验进展,可与免疫治疗相结合，以提高治疗效果。这种对GPCRs作用的扩展理解可能会阐明肿瘤进展的潜在机制，并为癌症免疫治疗提供新的视角。
