PDF(Pubmed)
Abstract：
BACKGROUND: Gelastic seizure (GS) is a rare type of epilepsy that most commonly appears in patients with hypothalamic hamartoma. It is rarely associated with other types of brain damage. This particular type of epilepsy is relatively rare and has few links to other brain lesions. Temporal lobe malacia is mostly caused by cerebral infarction or cerebral hemorrhage, which can lead to seizures. We report a case of GS in a woman with temporal lobe malacia which was reported for the first time in the literature.
METHODS: A 73-year-old female, diagnosed case of GS, presented with repetitive stereotyped laughter a month prior to presentation, happening multiple times daily and with each time lasting for 5-15s. Electroencephalogram displayed a focal seizure seen in the right temporal region. Magnetic resonance imaging head with contrast showed a right temporal lobe malacia. The patient was started on levetiracetam daily. The patient indicated that they had fully recovered and were not experiencing any recurrent or stereotyped laughter during their daily routines. These results remained consistent even after a one-year follow-up period.
CONCLUSIONS: GS can be caused by temporal lobe malacia, which is an uncommon but potentially grave condition. The outcome of this present case exhibited the importance of the temporal lobe in the genesis of GS.
METHODS: A 73-year-old female, diagnosed case of GS, presented with repetitive stereotyped laughter a month prior to presentation, happening multiple times daily and with each time lasting for 5-15s. Electroencephalogram displayed a focal seizure seen in the right temporal region. Magnetic resonance imaging head with contrast showed a right temporal lobe malacia. The patient was started on levetiracetam daily. The patient indicated that they had fully recovered and were not experiencing any recurrent or stereotyped laughter during their daily routines. These results remained consistent even after a one-year follow-up period.
CONCLUSIONS: GS can be caused by temporal lobe malacia, which is an uncommon but potentially grave condition. The outcome of this present case exhibited the importance of the temporal lobe in the genesis of GS.
摘要：
背景：弹性癫痫（GS）是一种罕见的癫痫类型，最常见于下丘脑错构瘤患者。它很少与其他类型的脑损伤有关。这种特殊类型的癫痫相对罕见，与其他脑部病变的联系很少。颞叶软化症主要由脑梗塞或脑出血引起，会导致癫痫发作.我们报道了一名患有颞叶软化症的女性的GS病例，这是文献中首次报道的。
方法：一位73岁的女性，诊断为GS的病例，在演讲前一个月出现重复刻板的笑声，每天发生多次，每次持续5-15秒。脑电图显示在右颞区可见局灶性癫痫发作。增强磁共振成像头显示右颞叶软化。患者开始每天服用左乙拉西坦。患者表示他们已经完全康复，并且在日常生活中没有经历任何反复或刻板的笑声。即使经过一年的随访，这些结果仍然保持一致。
结论：GS可由颞叶软化症引起，这是一种罕见但潜在严重的情况。本案的结果表明颞叶在GS发生中的重要性。
方法：一位73岁的女性，诊断为GS的病例，在演讲前一个月出现重复刻板的笑声，每天发生多次，每次持续5-15秒。脑电图显示在右颞区可见局灶性癫痫发作。增强磁共振成像头显示右颞叶软化。患者开始每天服用左乙拉西坦。患者表示他们已经完全康复，并且在日常生活中没有经历任何反复或刻板的笑声。即使经过一年的随访，这些结果仍然保持一致。
结论：GS可由颞叶软化症引起，这是一种罕见但潜在严重的情况。本案的结果表明颞叶在GS发生中的重要性。
