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Abstract：
Glioblastoma poses a formidable challenge among primary brain tumors: its tumorigenic stem cells, capable of self-renewal, proliferation, and differentiation, contribute substantially to tumor initiation and therapy resistance. These glioblastoma stem cells (GSCs), resembling conventional stem and progenitor cells, adopt pathways critical for tissue development and repair, promoting uninterrupted tumor expansion. Long non-coding RNAs (lncRNAs), a substantial component of the human transcriptome, have garnered considerable interest for their pivotal roles in normal physiological processes and cancer pathogenesis. They display cell- or tissue-specific expression patterns, and extensive investigations have highlighted their impact on regulating GSC properties and cellular differentiation, thus offering promising avenues for therapeutic interventions. Consequently, lncRNAs, with their ability to exert regulatory control over tumor initiation and progression, have emerged as promising targets for innovative glioblastoma therapies. This review explores notable examples of GSC-associated lncRNAs and elucidates their functional roles in driving glioblastoma progression. Additionally, we delved deeper into utilizing a 3D in vitro model for investigating GSC biology and elucidated four primary methodologies for targeting lncRNAs as potential therapeutics in managing glioblastoma.
摘要：
胶质母细胞瘤在原发性脑肿瘤中提出了巨大的挑战：其致瘤干细胞，能够自我更新，扩散,和差异化，对肿瘤发生和治疗抵抗有很大贡献。这些胶质母细胞瘤干细胞（GSC），类似于传统的干细胞和祖细胞，采用对组织发育和修复至关重要的途径，促进肿瘤不间断的扩张。长链非编码RNA（lncRNA），人类转录组的重要组成部分，它们在正常生理过程和癌症发病机理中的关键作用引起了相当大的兴趣。它们显示细胞或组织特异性表达模式，广泛的研究强调了它们对调节GSC特性和细胞分化的影响，从而为治疗干预提供了有希望的途径。因此,lncRNAs,它们能够对肿瘤的发生和发展施加调控控制，已经成为创新的胶质母细胞瘤治疗的有希望的目标。这篇综述探讨了GSC相关lncRNAs的值得注意的例子，并阐明了它们在驱动胶质母细胞瘤进展中的功能作用。此外,我们深入研究了利用3D体外模型来研究GSC生物学，并阐明了靶向lncRNAs作为治疗胶质母细胞瘤的潜在疗法的四种主要方法。
