UNASSIGNED: Cannabinoids have shown to reduce seizure activity and neuronal excitability in several epileptic models through the activation of muscarinic receptors with drugs which modulate their activity. Cannabinoids also have been effective in reducing antiepileptic activity in pharmaco-resistant individuals; however, the mechanism of its effects in temporal lobe epilepsy is not clear.
UNASSIGNED: This review seeks to elucidate the relationship between muscarinic and cannabinoid receptors in epilepsy and neural excitability.
■大麻素已显示出在几种癫痫模型中通过用调节其活性的药物激活毒蕈碱受体来降低癫痫发作活性和神经元兴奋性。大麻素也有效降低药物耐药个体的抗癫痫活性;然而,其在颞叶癫痫中的作用机制尚不清楚。
■这篇综述旨在阐明癫痫中毒蕈碱和大麻素受体与神经兴奋性之间的关系。