PDF(Pubmed)
Abstract：
UNASSIGNED: Of the seventy million people who suffer from epilepsy, 40 percent of them become resistant to more than one antiepileptic medication and have a higher chance of death. While the classical definition of epilepsy was due to the imbalance between excitatory glutamatergic and inhibitory γ-aminobutyric acid (GABA)-ergic signalling, substantial evidence implicates muscarinic receptors in the regulation of neural excitability.
UNASSIGNED: Cannabinoids have shown to reduce seizure activity and neuronal excitability in several epileptic models through the activation of muscarinic receptors with drugs which modulate their activity. Cannabinoids also have been effective in reducing antiepileptic activity in pharmaco-resistant individuals; however, the mechanism of its effects in temporal lobe epilepsy is not clear.
UNASSIGNED: This review seeks to elucidate the relationship between muscarinic and cannabinoid receptors in epilepsy and neural excitability.
UNASSIGNED: Cannabinoids have shown to reduce seizure activity and neuronal excitability in several epileptic models through the activation of muscarinic receptors with drugs which modulate their activity. Cannabinoids also have been effective in reducing antiepileptic activity in pharmaco-resistant individuals; however, the mechanism of its effects in temporal lobe epilepsy is not clear.
UNASSIGNED: This review seeks to elucidate the relationship between muscarinic and cannabinoid receptors in epilepsy and neural excitability.
摘要：
■在七千万患有癫痫的人中，其中40％的人对一种以上的抗癫痫药物产生抗药性，并且死亡的可能性更高。虽然癫痫的经典定义是由于兴奋性谷氨酸能和抑制性γ-氨基丁酸（GABA）-能信号之间的不平衡，大量证据表明毒蕈碱受体参与神经兴奋性的调节。
■大麻素已显示出在几种癫痫模型中通过用调节其活性的药物激活毒蕈碱受体来降低癫痫发作活性和神经元兴奋性。大麻素也有效降低药物耐药个体的抗癫痫活性；然而，其在颞叶癫痫中的作用机制尚不清楚。
■这篇综述旨在阐明癫痫中毒蕈碱和大麻素受体与神经兴奋性之间的关系。
■大麻素已显示出在几种癫痫模型中通过用调节其活性的药物激活毒蕈碱受体来降低癫痫发作活性和神经元兴奋性。大麻素也有效降低药物耐药个体的抗癫痫活性；然而，其在颞叶癫痫中的作用机制尚不清楚。
■这篇综述旨在阐明癫痫中毒蕈碱和大麻素受体与神经兴奋性之间的关系。
