Abstract：
Novel biomarkers reflecting the degree of immunosuppression in transplant patients are required to ensure eventual personalized equilibrium between rejection and infection risks. With the above aim, Torque Teno Virus (TTV) viremia was precisely examined in a large cohort of transplanted immunocompromised patients (192 hematological and 60 solid organ transplant recipients) being monitored for Cytomegalovirus reactivation. TTV load was measured in 2612 plasma samples from 448 patients. The results revealed a significant increase in TTV viral load approximately 14 days following CMV reactivation/infection in solid organ transplant (SOT) patients. No recognizable difference in TTV load was noted among hematological patients during the entire timeframe analyzed. Furthermore, a temporal gap of approximately 30 days was noted between the viral load peaks reached by the two viruses, with Cytomegalovirus (CMV) preceding TTV. It was not possible to establish a correlation between CMV reactivation/infection and TTV viremia in hematological patients. On the other hand, the SOT patient cohort allowed us to analyze viral kinetics and draw intriguing conclusions. Taken together, the data suggest, to our knowledge for the first time, that CMV infection itself could potentially cause an increase in TTV load in the peripheral blood of patients undergoing immunosuppressive therapy.
摘要：
需要反映移植患者免疫抑制程度的新型生物标志物，以确保排斥和感染风险之间的最终个性化平衡。为了实现上述目标，在接受巨细胞病毒再激活监测的大量免疫功能低下的移植患者（192例血液学和60例实体器官移植受者）中，对扭矩特诺病毒（TTV）病毒血症进行了精确检查。在来自448名患者的2612个血浆样品中测量TTV负荷。结果显示，实体器官移植（SOT）患者CMV再激活/感染后约14天，TTV病毒载量显着增加。在分析的整个时间范围内，血液学患者之间的TTV负荷没有可识别的差异。此外，在两种病毒达到的病毒载量峰值之间存在大约30天的时间间隔，巨细胞病毒（CMV）在TTV之前。在血液学患者中，无法建立CMV再激活/感染与TTV病毒血症之间的相关性。另一方面,SOT患者队列使我们能够分析病毒动力学并得出有趣的结论.一起来看,数据表明,我们第一次认识到,CMV感染本身可能导致接受免疫抑制治疗的患者外周血中TTV负荷增加。
