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Abstract：
BACKGROUND: Acute coronary syndrome (ACS) is one of the common causes of cardiovascular death. The related lncRNAs were novel approaches for early diagnosis and intervention. This paper focused on the clinical function of SNHG7 for patients after PCI.
METHODS: The expression of SNHG7 was assessed in ACS patients. The predictive roles of SNHG7 were unveiled by the ROC curve. The relationship between SNHG7 and Gensini scores was judged by Pearson analysis. One-year follow-up was conducted and all patients were catalogued into different groups based on the prognosis. The qRT-PCR, K-M curve, and Cox regression analysis were performed to document the prognostic significance of SNHG7.
RESULTS: SNHG7 was highly expressed in ACS and its three subtypes. SNHG7 showed a certain value in predicting ACS, UA, NSTEMI, and STEMI. Gensini is a closely correlated indicator of SNHG7. The declined expression of SNHG7 was observed in the non-MACE and survival groups. The risk of MACE and death was increased in the group with high expression of SNHG7. SNHG7 was an independent biomarker in patients with ACS after PCI.
CONCLUSIONS: SNHG7 might be a diagnostic and prognostic tool for ACS patients.
METHODS: The expression of SNHG7 was assessed in ACS patients. The predictive roles of SNHG7 were unveiled by the ROC curve. The relationship between SNHG7 and Gensini scores was judged by Pearson analysis. One-year follow-up was conducted and all patients were catalogued into different groups based on the prognosis. The qRT-PCR, K-M curve, and Cox regression analysis were performed to document the prognostic significance of SNHG7.
RESULTS: SNHG7 was highly expressed in ACS and its three subtypes. SNHG7 showed a certain value in predicting ACS, UA, NSTEMI, and STEMI. Gensini is a closely correlated indicator of SNHG7. The declined expression of SNHG7 was observed in the non-MACE and survival groups. The risk of MACE and death was increased in the group with high expression of SNHG7. SNHG7 was an independent biomarker in patients with ACS after PCI.
CONCLUSIONS: SNHG7 might be a diagnostic and prognostic tool for ACS patients.
摘要：
背景：急性冠脉综合征（ACS）是心血管死亡的常见原因之一。相关lncRNAs是早期诊断和干预的新方法。本文就SNHG7对PCI术后患者的临床功能进行综述。
方法：在ACS患者中评估SNHG7的表达。ROC曲线揭示了SNHG7的预测作用。通过Pearson分析判断SNHG7与Gensini评分的关系。进行了一年的随访，并根据预后将所有患者分为不同的组。qRT-PCR,K-M曲线,并进行Cox回归分析以记录SNHG7的预后意义。
结果：SNHG7在ACS及其三种亚型中高表达。SNHG7在预测ACS、UA,NSTEMI,和STEMI。Gensini是SNHG7的密切相关指标。在非MACE和存活组中观察到SNHG7的表达下降。SNHG7高表达组发生MACE和逝世亡的风险增加。SNHG7是ACS患者PCI术后的独立生物标志物。
结论：SNHG7可能是ACS患者的诊断和预后工具。
方法：在ACS患者中评估SNHG7的表达。ROC曲线揭示了SNHG7的预测作用。通过Pearson分析判断SNHG7与Gensini评分的关系。进行了一年的随访，并根据预后将所有患者分为不同的组。qRT-PCR,K-M曲线,并进行Cox回归分析以记录SNHG7的预后意义。
结果：SNHG7在ACS及其三种亚型中高表达。SNHG7在预测ACS、UA,NSTEMI,和STEMI。Gensini是SNHG7的密切相关指标。在非MACE和存活组中观察到SNHG7的表达下降。SNHG7高表达组发生MACE和逝世亡的风险增加。SNHG7是ACS患者PCI术后的独立生物标志物。
结论：SNHG7可能是ACS患者的诊断和预后工具。
