Abstract：
BACKGROUND: Hypertension is the most common reversible cause of cardiovascular disease worldwide and more than one billion individuals suffer from the disease. Constant heart exposure to increased afterload progresses to maladaptive remodeling, leading to cardiac dysfunction. In this study, we aimed to evaluate cardiac function in response to hypertension treatment.
METHODS: One hundred patients diagnosed with hypertension were evaluated two times, with 3 to 6 months intervals, before and after antihypertensive therapy. Patients underwent clinical and echocardiographic evaluation in both visits and the interest effect of antihypertensive therapy on cardiac function was studied.
RESULTS: 58 men and 42 women with a mean age of 60.81 ± 11.8 years were studied. Mean systolic and diastolic pressure in the first visit was 163.05 ± 20.6 and 95.40 ± 10.4, respectively. On the second visit, mean systolic and diastolic pressure was 129.95 ± 10.4 and 82.35 ± 7.2 respectively (P value for both < 0.001). The mean value of Global Longitudinal Strain as the main parameter for evaluating left ventricular systolic function was -15.54% on the first visit and changed to -16.95% on the second visit (P value 0.025).
CONCLUSIONS: According to the results of this study, changes in parameters, indicator of systolic and diastolic function, after 3-6 months of antihypertensive therapy are significant. The most important point is that maladaptive remodeling of the heart is reversible if hypertension is diagnosed timely. To follow-up patients under antihypertensive therapy, GLS and parameters indicator of diastolic dysfunction, have the best diagnostic value in terms of detecting early stages of cardiac injury.
METHODS: One hundred patients diagnosed with hypertension were evaluated two times, with 3 to 6 months intervals, before and after antihypertensive therapy. Patients underwent clinical and echocardiographic evaluation in both visits and the interest effect of antihypertensive therapy on cardiac function was studied.
RESULTS: 58 men and 42 women with a mean age of 60.81 ± 11.8 years were studied. Mean systolic and diastolic pressure in the first visit was 163.05 ± 20.6 and 95.40 ± 10.4, respectively. On the second visit, mean systolic and diastolic pressure was 129.95 ± 10.4 and 82.35 ± 7.2 respectively (P value for both < 0.001). The mean value of Global Longitudinal Strain as the main parameter for evaluating left ventricular systolic function was -15.54% on the first visit and changed to -16.95% on the second visit (P value 0.025).
CONCLUSIONS: According to the results of this study, changes in parameters, indicator of systolic and diastolic function, after 3-6 months of antihypertensive therapy are significant. The most important point is that maladaptive remodeling of the heart is reversible if hypertension is diagnosed timely. To follow-up patients under antihypertensive therapy, GLS and parameters indicator of diastolic dysfunction, have the best diagnostic value in terms of detecting early stages of cardiac injury.
摘要：
背景：高血压是全球心血管疾病最常见的可逆原因，超过10亿人患有这种疾病。持续的心脏暴露于增加的后负荷进展为适应不良的重塑，导致心脏功能障碍.在这项研究中,我们旨在评估高血压治疗后的心功能.
方法：对100例诊断为高血压的患者进行两次评估，间隔3到6个月，降压治疗前后。在两次访问中都对患者进行了临床和超声心动图评估，并研究了降压治疗对心脏功能的兴趣效应。
结果：研究了58名男性和42名女性，平均年龄为60.81±11.8岁。首次就诊的平均收缩压和舒张压分别为163.05±20.6和95.40±10.4。第二次访问时，平均收缩压和舒张压分别为129.95±10.4和82.35±7.2（两者的P值均<0.001）。作为评估左心室收缩功能的主要参数的全局纵向应变的平均值在第一次就诊时为-15.54％，在第二次就诊时为-16.95％（P值0.025）。
结论：根据本研究的结果，参数的变化，收缩和舒张功能的指标，经过3-6个月的降压治疗是显著的。最重要的一点是，如果及时诊断高血压，心脏的适应不良重塑是可逆的。对接受降压治疗的患者进行随访,GLS和舒张功能不全的参数指标，在检测心脏损伤的早期阶段方面具有最佳诊断价值。
方法：对100例诊断为高血压的患者进行两次评估，间隔3到6个月，降压治疗前后。在两次访问中都对患者进行了临床和超声心动图评估，并研究了降压治疗对心脏功能的兴趣效应。
结果：研究了58名男性和42名女性，平均年龄为60.81±11.8岁。首次就诊的平均收缩压和舒张压分别为163.05±20.6和95.40±10.4。第二次访问时，平均收缩压和舒张压分别为129.95±10.4和82.35±7.2（两者的P值均<0.001）。作为评估左心室收缩功能的主要参数的全局纵向应变的平均值在第一次就诊时为-15.54％，在第二次就诊时为-16.95％（P值0.025）。
结论：根据本研究的结果，参数的变化，收缩和舒张功能的指标，经过3-6个月的降压治疗是显著的。最重要的一点是，如果及时诊断高血压，心脏的适应不良重塑是可逆的。对接受降压治疗的患者进行随访,GLS和舒张功能不全的参数指标，在检测心脏损伤的早期阶段方面具有最佳诊断价值。
