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Abstract：
Studies investigating the relationship between dietary vitamin B1 intake and risk of Hyperuricemia (HU) are scarce, the present study aimed to examine the association of dietary vitamin B1 intake and HU among adults. This cross-sectional study included 5750 adults whose data derived from National Health and Nutrition Examination Survey (NHANES) from March 2017 to March 2020. The dietary intake of vitamin B1 was assessed using 24-h dietary recall interviews. The characteristics of study participants were grouped into five levels according to the levels of vitamin B1 quintile. Multivariate logistic regression analysis was used to estimate the odds ratio (OR) and 95% confidence interval (CI) of HU, according to the vitamin B1 intake quintile for male and female separately. The dose-response relationship was determined by the restricted cubic spline (RCS). Smoothed curve fitting was used to assess serum uric acid concentration versus dietary vitamin B1 intake in the study population. The prevalence of hyperuricemia was 18.90% (20.15% and 17.79% for males and females, respectively) in the United States from March 2017 to March 2020. Multiple logistic regression analyses showed that in the male population, the HU ratio (OR) of vitamin B1 intake in Q2 to Q5 compared with the lowest quintile (Q1) was 0.75 (95% CI 0.52, 1.09), 0.70 (95% CI 0.48, 1.02), 0.66 (95% CI 0.44, 0.99) and 0.55 (95% CI 0.34, 0.90). The P for trend was 0.028. In women, the ORs for vitamin B1 intake Q2 to Q5 were 0.87 (95% CI 0.64, 1.19), 0.97 (0.68-1.38), 1.05 (0.69-1.60) and 0.75 (0.42-1.34), respectively. The P for trend was 0.876. The RCS curve revealed a linear relationship between vitamin B1 intake and the risk of hyperuricemia in men (P nonlinear = 0.401). Smoothed curve fitting demonstrated a negative association between vitamin B1 intake and serum uric acid concentration in men, whereas there was no significant association between dietary vitamin B1 intake and the risk of hyperuricemia in women. In the US adult population, dietary vitamin B1 intake was negatively associated with hyperuricemia in males.
摘要：
调查膳食维生素B1摄入量与高尿酸血症（HU）风险之间关系的研究很少，本研究旨在研究成人膳食维生素B1摄入与HU的关系.这项横断面研究包括5750名成年人，其数据来自2017年3月至2020年3月的国家健康和营养检查调查（NHANES）。使用24小时饮食回忆访谈评估维生素B1的饮食摄入量。根据维生素B1五分之一的水平，将研究参与者的特征分为五个级别。采用多因素logistic回归分析估算HU的比值比(OR)和95%置信区间(CI),根据维生素B1的摄入量，男性和女性分别为五分之一。剂量-反应关系由受限三次样条(RCS)确定。平滑曲线拟合用于评估研究人群中血清尿酸浓度与膳食维生素B1摄入量的关系。高尿酸血症患病率为18.90%(男女分别为20.15%和17.79%,分别）从2017年3月到2020年3月在美国。多因素Logistic回归分析显示，在男性人群中，与最低五分之一(Q1)相比，Q2至Q5维生素B1摄入量的HU比率(OR)为0.75(95%CI0.52,1.09)，0.70（95%CI0.48，1.02），0.66（95%CI0.44，0.99）和0.55（95%CI0.34，0.90）。趋势的P为0.028。在女性中，维生素B1摄入Q2至Q5的OR为0.87(95%CI0.64，1.19)，0.97（0.68-1.38），1.05（0.69-1.60）和0.75（0.42-1.34），分别。趋势的P为0.876。RCS曲线显示维生素B1摄入量与男性高尿酸血症风险之间存在线性关系（P非线性=0.401）。平滑曲线拟合显示，男性维生素B1摄入量与血清尿酸浓度呈负相关，而膳食维生素B1摄入量与女性高尿酸血症风险之间没有显著关联.在美国成年人口中，男性饮食中维生素B1的摄入与高尿酸血症呈负相关。
