Abstract：
OBJECTIVE: The aim of this report was to provide a clinical description and clinical, ultrasonographic, and histologic images of a foal with microphthalmia and multiple ocular abnormalities.
METHODS: A 12-h old Friesian-American Paint Horse crossbred filly presented for blindness, microphthalmia and marked ventral strabismus in both eyes.
METHODS: A complete ophthalmic examination was performed. Ultrasound biomicroscopy and B-mode ultrasonography were performed. The globes were submitted for histopathology.
RESULTS: Ultrasound biomicroscopy demonstrated a hyperechoic cornea void of the typical epithelium, stroma, and Descemet\'s membrane layers. The anterior chamber was spanned by thick strands of hyperechoic tissue extending from the iris to the cornea. The lens was not visualized. B-mode ultrasound showed aphakia and mild, mottled echogenicity within the vitreous with no evidence of retinal detachment. On histopathology, both globes were microphthalmic with poorly defined corneal tissue. The anterior chambers were poorly formed and contained lacrimal glandular tissue. Portions of iridal tissue were present, but no lenses were noted. The retinas were segmentally detached and markedly atrophied with areas of retina dysplasia noted.
CONCLUSIONS: This report provides a clinical, ultrasonographic and histologic description of a rare, congenital condition in a foal characterized by microphthalmia, aphakia, poorly defined corneal tissue, choristomatous differentiation of the anterior segment and retinal dysplasia.
METHODS: A 12-h old Friesian-American Paint Horse crossbred filly presented for blindness, microphthalmia and marked ventral strabismus in both eyes.
METHODS: A complete ophthalmic examination was performed. Ultrasound biomicroscopy and B-mode ultrasonography were performed. The globes were submitted for histopathology.
RESULTS: Ultrasound biomicroscopy demonstrated a hyperechoic cornea void of the typical epithelium, stroma, and Descemet\'s membrane layers. The anterior chamber was spanned by thick strands of hyperechoic tissue extending from the iris to the cornea. The lens was not visualized. B-mode ultrasound showed aphakia and mild, mottled echogenicity within the vitreous with no evidence of retinal detachment. On histopathology, both globes were microphthalmic with poorly defined corneal tissue. The anterior chambers were poorly formed and contained lacrimal glandular tissue. Portions of iridal tissue were present, but no lenses were noted. The retinas were segmentally detached and markedly atrophied with areas of retina dysplasia noted.
CONCLUSIONS: This report provides a clinical, ultrasonographic and histologic description of a rare, congenital condition in a foal characterized by microphthalmia, aphakia, poorly defined corneal tissue, choristomatous differentiation of the anterior segment and retinal dysplasia.
摘要：
目的：本报告的目的是提供临床描述和临床，超声检查,和小眼病和多发性眼部异常的小马驹的组织学图像。
方法：一只12小时大的美洲裔油漆马杂交雌马因失明而出现，双眼小眼症和明显的腹侧斜视。
方法：进行完整的眼科检查。进行超声生物显微镜和B超检查。这些球被提交用于组织病理学。
结果：超声生物显微镜检查显示典型上皮的高回声角膜空隙，基质,和Descemet的膜层。前房被从虹膜延伸到角膜的厚厚的高回声组织所跨越。透镜没有可视化。B超显示无晶状体和轻度,玻璃体内斑驳的回声，没有视网膜脱离的证据。在组织病理学上，两个球均为微眼科,角膜组织不明确.前房形成不良，包含泪腺组织。存在部分虹膜组织，但没有注意到镜片。视网膜分段分离，并明显萎缩，并注意到视网膜发育不良区域。
结论：本报告提供了临床，一种罕见的超声和组织学描述，以小眼畸形为特征的小马驹的先天性疾病，无晶状体,定义不清的角膜组织，眼前段的脉络膜分化和视网膜发育不良。
方法：一只12小时大的美洲裔油漆马杂交雌马因失明而出现，双眼小眼症和明显的腹侧斜视。
方法：进行完整的眼科检查。进行超声生物显微镜和B超检查。这些球被提交用于组织病理学。
结果：超声生物显微镜检查显示典型上皮的高回声角膜空隙，基质,和Descemet的膜层。前房被从虹膜延伸到角膜的厚厚的高回声组织所跨越。透镜没有可视化。B超显示无晶状体和轻度,玻璃体内斑驳的回声，没有视网膜脱离的证据。在组织病理学上，两个球均为微眼科,角膜组织不明确.前房形成不良，包含泪腺组织。存在部分虹膜组织，但没有注意到镜片。视网膜分段分离，并明显萎缩，并注意到视网膜发育不良区域。
结论：本报告提供了临床，一种罕见的超声和组织学描述，以小眼畸形为特征的小马驹的先天性疾病，无晶状体,定义不清的角膜组织，眼前段的脉络膜分化和视网膜发育不良。
