Abstract：
BACKGROUND: Vaso-occlusive crisis causing severe pain can be seen in patients with sickle cell anemia and potent opioids should be used in this process. Although sickle cell disease (SCD) patients use patient-controlled analgesia (PCA), we encountered no study evaluating this method from the participants\' perspective.
OBJECTIVE: This descriptive study aimed to evaluate the use and effectiveness of PCA administered using the Mersin Algology Protocol (MAP) during painful episodes of SCD based on participants reports.
METHODS: After obtaining approval from the local ethics committee, 109 SCD participants using PCA as per the MAP between 2018 and 2020 were recruited for the study. The participants answered a 28-item questionnaire regarding their annual number of pain crises, sites of pain, knowledge about PCA, the number of times they used PCA, and the positive and negative aspects of the PCA method.
RESULTS: The mean age of the participants was 28.80 ± 11.5 years. Ninety-nine (90.8%) of the participants considered PCA superior to other pain management methods they had used previously. The 53 participants (48.6%) who waited for their pain to worsen before administering the demand dose expressed fear of taking high doses of medication. As the number of times a participant used PCA increased, NRS scores for pain at the time of demand dosing decreased from 7-10 to 4-6 (p = .013). Eighty-five (78%) of the participants reported having no problems related to the device or drug while using PCA.
CONCLUSIONS: We found that PCA was used more correctly by participants with more experience using the device. Participants who delay demand dosing do so because of anxiety about developing dependence and to avoid high doses.
OBJECTIVE: This descriptive study aimed to evaluate the use and effectiveness of PCA administered using the Mersin Algology Protocol (MAP) during painful episodes of SCD based on participants reports.
METHODS: After obtaining approval from the local ethics committee, 109 SCD participants using PCA as per the MAP between 2018 and 2020 were recruited for the study. The participants answered a 28-item questionnaire regarding their annual number of pain crises, sites of pain, knowledge about PCA, the number of times they used PCA, and the positive and negative aspects of the PCA method.
RESULTS: The mean age of the participants was 28.80 ± 11.5 years. Ninety-nine (90.8%) of the participants considered PCA superior to other pain management methods they had used previously. The 53 participants (48.6%) who waited for their pain to worsen before administering the demand dose expressed fear of taking high doses of medication. As the number of times a participant used PCA increased, NRS scores for pain at the time of demand dosing decreased from 7-10 to 4-6 (p = .013). Eighty-five (78%) of the participants reported having no problems related to the device or drug while using PCA.
CONCLUSIONS: We found that PCA was used more correctly by participants with more experience using the device. Participants who delay demand dosing do so because of anxiety about developing dependence and to avoid high doses.
摘要：
背景：在镰状细胞性贫血患者中可以看到引起严重疼痛的血管闭塞危象，在此过程中应使用有效的阿片类药物。尽管镰状细胞病（SCD）患者使用患者自控镇痛（PCA），我们没有从参与者的角度评估这种方法的研究。
目的：这项描述性研究旨在根据参与者报告评估在SCD疼痛发作期间使用MersinAlgologyProtocol（MAP）进行PCA的使用和有效性。
方法：获得当地伦理委员会批准后，根据2018年至2020年的MAP使用PCA的109名SCD参与者被招募用于研究。参与者回答了关于他们每年疼痛危机次数的28项问卷，疼痛部位,关于PCA的知识，他们使用PCA的次数，以及PCA方法的积极和消极方面。
结果：参与者的平均年龄为28.80±11.5岁。九十九（90.8%）的参与者认为PCA优于他们以前使用的其他疼痛管理方法。53名参与者（48.6％）在服用需求剂量之前等待疼痛恶化表示担心服用高剂量药物。随着参与者使用PCA的次数增加，在需要给药时疼痛的NRS评分从7-10下降到4-6(p=0.013)。85（78％）的参与者报告在使用PCA时没有与设备或药物相关的问题。
结论：我们发现，具有更多使用该设备经验的参与者更正确地使用了PCA。推迟要求给药的参与者这样做是因为对发展依赖性的焦虑和避免高剂量。
目的：这项描述性研究旨在根据参与者报告评估在SCD疼痛发作期间使用MersinAlgologyProtocol（MAP）进行PCA的使用和有效性。
方法：获得当地伦理委员会批准后，根据2018年至2020年的MAP使用PCA的109名SCD参与者被招募用于研究。参与者回答了关于他们每年疼痛危机次数的28项问卷，疼痛部位,关于PCA的知识，他们使用PCA的次数，以及PCA方法的积极和消极方面。
结果：参与者的平均年龄为28.80±11.5岁。九十九（90.8%）的参与者认为PCA优于他们以前使用的其他疼痛管理方法。53名参与者（48.6％）在服用需求剂量之前等待疼痛恶化表示担心服用高剂量药物。随着参与者使用PCA的次数增加，在需要给药时疼痛的NRS评分从7-10下降到4-6(p=0.013)。85（78％）的参与者报告在使用PCA时没有与设备或药物相关的问题。
结论：我们发现，具有更多使用该设备经验的参与者更正确地使用了PCA。推迟要求给药的参与者这样做是因为对发展依赖性的焦虑和避免高剂量。
