Abstract：
OBJECTIVE: To investigate thermoregulation, thermal antinociception, food/kaolin intake, fecal output, and behavior following long-acting buprenorphine preparations in rats.
METHODS: 8 adult male rats (Rattus norvegicus) were administered long-acting SC buprenorphine (SB; 0.65 mg/kg), transdermal buprenorphine (TB; 10 mg/kg), and controls in a randomized, cross-over design.
METHODS: Body temperature, self-injury, sedation, food/kaolin intake, fecal output, and thermal withdrawal latencies were measured 1, 4, 8, 12, 24, 48, and 72 hours posttreatment. Data analysis was performed with mixed linear models.
RESULTS: Self-injury was present between 1 and 12 hours and 4 and 12 hours following TB and SB, respectively; sedation was associated with TB at 12 to 24 hours. Withdrawal latencies were longer in both TB and SB groups than in the control group. Food intake decreased with time in all groups but was significantly lower 24 to 48 hours after TB and 24 to 72 hours after SB versus controls. Kaolin intake decreased from baseline 48 to 72 hours in the control group. Fecal output decreased from baseline 24 to 72 hours in all groups but was significantly lower than controls 24 hours following TB and 24 to 48 hours in SB. Body temperature increased from baseline at 1 hour, 1 to 12 hours, and 1 to 24 hours in the control, TB, and SB groups, respectively, and was significantly higher than the control group 1 to 72 hours following TB and 4 to 24 hours after SB. Transdermal buprenorphine and SB in normal rats produced antinociception, self-injurious behavior, hyperthermia, and decreased food/fecal output.
CONCLUSIONS: Although these buprenorphine preparations may produce antinociception, untoward effects such as hyperthermia, self-injurious behavior, and reduced food intake/fecal output may be seen.
METHODS: 8 adult male rats (Rattus norvegicus) were administered long-acting SC buprenorphine (SB; 0.65 mg/kg), transdermal buprenorphine (TB; 10 mg/kg), and controls in a randomized, cross-over design.
METHODS: Body temperature, self-injury, sedation, food/kaolin intake, fecal output, and thermal withdrawal latencies were measured 1, 4, 8, 12, 24, 48, and 72 hours posttreatment. Data analysis was performed with mixed linear models.
RESULTS: Self-injury was present between 1 and 12 hours and 4 and 12 hours following TB and SB, respectively; sedation was associated with TB at 12 to 24 hours. Withdrawal latencies were longer in both TB and SB groups than in the control group. Food intake decreased with time in all groups but was significantly lower 24 to 48 hours after TB and 24 to 72 hours after SB versus controls. Kaolin intake decreased from baseline 48 to 72 hours in the control group. Fecal output decreased from baseline 24 to 72 hours in all groups but was significantly lower than controls 24 hours following TB and 24 to 48 hours in SB. Body temperature increased from baseline at 1 hour, 1 to 12 hours, and 1 to 24 hours in the control, TB, and SB groups, respectively, and was significantly higher than the control group 1 to 72 hours following TB and 4 to 24 hours after SB. Transdermal buprenorphine and SB in normal rats produced antinociception, self-injurious behavior, hyperthermia, and decreased food/fecal output.
CONCLUSIONS: Although these buprenorphine preparations may produce antinociception, untoward effects such as hyperthermia, self-injurious behavior, and reduced food intake/fecal output may be seen.
摘要：
目的：研究体温调节，热抗伤害感受，食物/高岭土摄入量，粪便输出，大鼠长效丁丙诺啡制剂后的行为。
方法：8只成年雄性大鼠给予长效SC丁丙诺啡（SB;0.65mg/kg），经皮丁丙诺啡（TB;10mg/kg），和随机控制，交叉设计。
方法：体温，自我伤害,镇静,食物/高岭土摄入量，粪便输出，治疗后1、4、8、12、24、48和72小时测量热戒断潜伏期。采用混合线性模型进行数据分析。
结果：在TB和SB之后的1至12小时和4至12小时之间存在自伤，分别;镇静与结核病在12至24小时相关。TB和SB组的戒断潜伏期均长于对照组。所有组的食物摄入量均随时间下降，但在TB后24至48小时和SB后24至72小时明显低于对照组。在对照组中,高岭土的摄入量从基线48小时减少到72小时。在所有组中,粪便输出从基线24至72小时降低,但在TB后24小时和SB中24至48小时显著低于对照。体温在1小时时从基线升高，1到12小时,在对照中1到24小时，TB,和SB组，分别,并且在TB后1至72小时和SB后4至24小时显着高于对照组。丁丙诺啡和SB在正常大鼠中产生镇痛感受，自我伤害的行为，热疗,食物/粪便输出减少。
结论：尽管这些丁丙诺啡制剂可能会产生镇痛作用，不利的影响，如热疗，自我伤害的行为，和减少的食物摄入量/粪便输出可以看到。
方法：8只成年雄性大鼠给予长效SC丁丙诺啡（SB;0.65mg/kg），经皮丁丙诺啡（TB;10mg/kg），和随机控制，交叉设计。
方法：体温，自我伤害,镇静,食物/高岭土摄入量，粪便输出，治疗后1、4、8、12、24、48和72小时测量热戒断潜伏期。采用混合线性模型进行数据分析。
结果：在TB和SB之后的1至12小时和4至12小时之间存在自伤，分别;镇静与结核病在12至24小时相关。TB和SB组的戒断潜伏期均长于对照组。所有组的食物摄入量均随时间下降，但在TB后24至48小时和SB后24至72小时明显低于对照组。在对照组中,高岭土的摄入量从基线48小时减少到72小时。在所有组中,粪便输出从基线24至72小时降低,但在TB后24小时和SB中24至48小时显著低于对照。体温在1小时时从基线升高，1到12小时,在对照中1到24小时，TB,和SB组，分别,并且在TB后1至72小时和SB后4至24小时显着高于对照组。丁丙诺啡和SB在正常大鼠中产生镇痛感受，自我伤害的行为，热疗,食物/粪便输出减少。
结论：尽管这些丁丙诺啡制剂可能会产生镇痛作用，不利的影响，如热疗，自我伤害的行为，和减少的食物摄入量/粪便输出可以看到。
