Abstract：
Cysteine cathepsins constitute the largest cathepsin family, with 11 proteases in human that are present primarily within acidic endosomal and lysosomal compartments. They are involved in the turnover of intracellular and extracellular proteins. They are synthesized as inactive procathepsins that are converted to mature active forms. Cathepsins play important roles in physiological and pathological processes and, therefore, receive increasing attention as potential therapeutic targets. Their maturation and activity can be regulated by glycosaminoglycans (GAGs), long linear negatively charged polysaccharides composed of recurring dimeric units. In this review, we summarize recent computational progress in the field of (pro)cathepsin-GAG complexes analyses.
摘要：
半胱氨酸组织蛋白酶构成了最大的组织蛋白酶家族，人类中的11种蛋白酶主要存在于酸性内体和溶酶体区室中。它们参与细胞内和细胞外蛋白质的周转。它们被合成为转化为成熟活性形式的非活性原肽素。组织蛋白酶在生理和病理过程中发挥重要作用,因此,作为潜在的治疗靶点受到越来越多的关注。它们的成熟和活性可以通过糖胺聚糖（GAG）调节，由重复的二聚体单元组成的长线性带负电荷的多糖。在这次审查中,我们总结了（前）组织蛋白酶-GAG复合物分析领域的最新计算进展。
