Abstract：
Bufadienolides, specifically bufalin, have garnered attention for their potential therapeutic application in modulating inflammatory pathways. Bufalin is derived from toad venom and exhibits promising anti-inflammatory properties. Its anti-inflammatory effects have been demonstrated by influencing crucial signaling pathways like NF-B, MAPK, and JAK-STAT, resulting in the inhibition of pro-inflammatory substances like cytokines, chemokines, and adhesion molecules. Bufalin blocks inflammasome activation and reduces oxidative stress, hence increasing its anti-inflammatory properties. Bufalin has shown effectiveness in reducing inflammation-related diseases such as cancer, cardiovascular problems, and autoimmune ailments in preclinical investigations. Furthermore, producing new approaches of medication delivery and combining therapies with bufalin shows potential for improving its effectiveness and reducing adverse effects. This review explores the pharmacological effects and mechanistic approaches of bufalin as an anti-inflammatory agent, which further highlights its potential for therapy and offers the basis for further study on its therapeutic application in inflammation-related disorders.
摘要：
Bufadienolides,特别是Bufalin,它们在调节炎症途径方面的潜在治疗应用引起了关注。Bufalin源自蟾蜍毒液，并表现出有希望的抗炎特性。它的抗炎作用已被证明通过影响关键信号通路，如NF-B，MAPK,还有JAK-STAT,导致细胞因子等促炎物质的抑制，趋化因子,和粘附分子。Bufalin阻断炎性体激活并减少氧化应激，从而增加其抗炎特性。Bufalin已显示出有效减少炎症相关疾病，如癌症，心血管问题,和临床前研究中的自身免疫性疾病。此外，产生新的药物输送方法和与bufalin联合治疗显示出提高其有效性和减少不良反应的潜力。这篇综述探讨了蟾蜍灵作为抗炎药的药理作用和机理。这进一步突出了其治疗潜力，并为进一步研究其在炎症相关疾病中的治疗应用提供了基础。
