PDF(Pubmed)
Abstract：
Aim: Nano-hydroxyapatite (nHA) is a good nanocarrier to load 223Ra, but the low specific activity (sp.act.) of 223Ra@nHA limits its application in medicine. Methods: We proposed a method for preparing nHA using PEG as a template, which significantly increases the sp.act of 223Ra@nHA and a new method to loaded 99mTc for in vivo tracking. Results: The nHA synthesized using PEG as a template was associated with higher sp.act for 223Ra in comparison to nHA with identical particle size and without PEG. The nHA load 99mTc-MDP was associated with higher labeling rate and stability in comparison to 99mTc. Conclusion: All these findings suggest that using PEG as a template and 99mTc-MDP could be the most effective of synthetic 223Ra/99mTc@nHA.
[Box: see text].
[Box: see text].
摘要：
目的:纳米羟基磷灰石(nHA)是负载223Ra的良好纳米载体,但比活度低(sp.act.)的223Ra@nHA限制了其在医学上的应用。方法：我们提出了一种以PEG为模板制备nHA的方法，这显著增加了sp。223Ra@nHA的作用和加载99mTc用于体内跟踪的新方法。结果：使用PEG作为模板合成的nHA与较高的sp。与具有相同粒度且不含PEG的nHA相比,对223Ra起作用。与99mTc相比，nHA负载99mTc-MDP与更高的标记率和稳定性相关。结论:所有这些发现表明,使用PEG作为模板和99mTc-MDP可能是最有效的合成223Ra/99mTc@nHA。
[方框：见正文]。
[方框：见正文]。
