PDF(Pubmed)
Abstract：
UNASSIGNED: Cerebrovascular complications are feared but also commonly reported in patients with COVID-19 requiring extracorporeal membrane oxygenation (ECMO) support therapy. Besides other reasons, a connection between impaired cerebral autoregulation and SARS-CoV-2 infection as a mechanism for an increase in cerebrovascular complications has been hypothesized.
UNASSIGNED: In an observational single-center study, we investigated a cohort of 48 patients requiring veno-venous ECMO support therapy with (n = 31) and without SARS-CoV-2 infection (n = 17). Cerebral autoregulation was assessed with the cerebral oximetry-derived autoregulation index (ORx) based on a moving correlation between arterial pressure and cerebral oximetry.
UNASSIGNED: Patients with ECMO support therapy and SARS-CoV-2 experienced more time with impaired cerebral autoregulation than without SARS-CoV-2 [17 ± 9 vs. 13 ± 9% (p = 0.027)]. Patients with SARS-CoV-2 suffering from cerebrovascular complications had more time with impaired autoregulation than non SARS-CoV-2 patients with these complications (19 ± 9 vs. 10 ± 4%, p = 0.032).
UNASSIGNED: Our results suggest a connection between SARS-CoV-2 and impaired cerebral autoregulation as well as cerebrovascular complications in SARS-CoV-2 patients.
UNASSIGNED: In an observational single-center study, we investigated a cohort of 48 patients requiring veno-venous ECMO support therapy with (n = 31) and without SARS-CoV-2 infection (n = 17). Cerebral autoregulation was assessed with the cerebral oximetry-derived autoregulation index (ORx) based on a moving correlation between arterial pressure and cerebral oximetry.
UNASSIGNED: Patients with ECMO support therapy and SARS-CoV-2 experienced more time with impaired cerebral autoregulation than without SARS-CoV-2 [17 ± 9 vs. 13 ± 9% (p = 0.027)]. Patients with SARS-CoV-2 suffering from cerebrovascular complications had more time with impaired autoregulation than non SARS-CoV-2 patients with these complications (19 ± 9 vs. 10 ± 4%, p = 0.032).
UNASSIGNED: Our results suggest a connection between SARS-CoV-2 and impaired cerebral autoregulation as well as cerebrovascular complications in SARS-CoV-2 patients.
摘要：
■在需要体外膜氧合（ECMO）支持治疗的COVID-19患者中，脑血管并发症令人担忧，但也普遍报道。除了其他原因,有人假设大脑自动调节受损与SARS-CoV-2感染之间存在联系，这是脑血管并发症增加的一种机制。
■在一项单中心观察性研究中，我们调查了48例需要静脉-静脉ECMO支持治疗且有SARS-CoV-2感染(n=31)和无SARS-CoV-2感染(n=17)的患者的队列.根据动脉压和脑血氧饱和度之间的移动相关性，使用脑血氧饱和度衍生的自动调节指数（ORx）评估脑自动调节。
■接受ECMO支持治疗和SARS-CoV-2的患者大脑自动调节受损的时间比没有SARS-CoV-2的患者长[17±9vs.13±9%(p=0.027)]。患有脑血管并发症的SARS-CoV-2患者比患有这些并发症的非SARS-CoV-2患者具有更多的自动调节受损时间（19±9vs.10±4%,p=0.032)。
■我们的结果表明，SARS-CoV-2与SARS-CoV-2患者的脑自动调节受损以及脑血管并发症之间存在联系。
■在一项单中心观察性研究中，我们调查了48例需要静脉-静脉ECMO支持治疗且有SARS-CoV-2感染(n=31)和无SARS-CoV-2感染(n=17)的患者的队列.根据动脉压和脑血氧饱和度之间的移动相关性，使用脑血氧饱和度衍生的自动调节指数（ORx）评估脑自动调节。
■接受ECMO支持治疗和SARS-CoV-2的患者大脑自动调节受损的时间比没有SARS-CoV-2的患者长[17±9vs.13±9%(p=0.027)]。患有脑血管并发症的SARS-CoV-2患者比患有这些并发症的非SARS-CoV-2患者具有更多的自动调节受损时间（19±9vs.10±4%,p=0.032)。
■我们的结果表明，SARS-CoV-2与SARS-CoV-2患者的脑自动调节受损以及脑血管并发症之间存在联系。
