PDF(Pubmed)
Abstract：
UNASSIGNED: Healthcare-associated infections (HAIs) in intensive care unit (ICU) patients significantly complicate the normal hospitalization process and affect patients\' condition, length of hospitalization, mortality, and treatment cost. In this study, we aimed to determine the prevalence and economic burden of HAIs.
UNASSIGNED: The study involved all patients with a confirmed HAIs (based on CDC/NHSN case-definitions); in the general ICU of a tertiary university hospital in Tehran, from April 2020 to March 2021. The patients\' information, including length of hospitalization, outcome, type and cost of prescribed antibiotics, were recorded.
UNASSIGNED: During the study period, 119 HAIs were found in 1395 (43% F / 57% M) patients. The prevalence of nosocomial infections was 8.53%. The mean duration of hospitalization in all ICU patients was 4.7 ± 3.1 days, and 31.85 ± 18.96 days in patients with HAIs. The most common organisms involved in HAIs are Acinetobacter baumannii (54.6%), Klebsiella pneumoniae (30.3%), E. coli (15.1%), and Enterococcus spp. (12%). Incidence density of ventilator-associated pneumonia (VAP), central line-associated bloodstream infection (CLA-BSI), and catheter-associated urinary tract infection (CA-UTI) per 1000 device-days were 36.08, 17.57, and 8.86, respectively. The total cost of antibiotics for HAIs was € 105,407. Among these, the highest consumption costs were for carbapenems, followed by colistin and caspofungin.
UNASSIGNED: This study showed the high burden of nosocomial infections in ICUs. Strategies for more strict infection prevention and control are necessary to reduce this burden.
UNASSIGNED: The study involved all patients with a confirmed HAIs (based on CDC/NHSN case-definitions); in the general ICU of a tertiary university hospital in Tehran, from April 2020 to March 2021. The patients\' information, including length of hospitalization, outcome, type and cost of prescribed antibiotics, were recorded.
UNASSIGNED: During the study period, 119 HAIs were found in 1395 (43% F / 57% M) patients. The prevalence of nosocomial infections was 8.53%. The mean duration of hospitalization in all ICU patients was 4.7 ± 3.1 days, and 31.85 ± 18.96 days in patients with HAIs. The most common organisms involved in HAIs are Acinetobacter baumannii (54.6%), Klebsiella pneumoniae (30.3%), E. coli (15.1%), and Enterococcus spp. (12%). Incidence density of ventilator-associated pneumonia (VAP), central line-associated bloodstream infection (CLA-BSI), and catheter-associated urinary tract infection (CA-UTI) per 1000 device-days were 36.08, 17.57, and 8.86, respectively. The total cost of antibiotics for HAIs was € 105,407. Among these, the highest consumption costs were for carbapenems, followed by colistin and caspofungin.
UNASSIGNED: This study showed the high burden of nosocomial infections in ICUs. Strategies for more strict infection prevention and control are necessary to reduce this burden.
摘要：
■重症监护病房（ICU）患者的医疗保健相关感染（HAIs）会使正常的住院过程复杂化，并影响患者的病情，住院时间,死亡率,和治疗费用。在这项研究中,我们旨在确定HAIs的患病率和经济负担。
■该研究涉及所有确诊HAIs的患者（基于CDC/NHSN病例定义）；在德黑兰一所三级大学医院的普通ICU中，从2020年4月到2021年3月。病人的信息，包括住院时间,结果,处方抗生素的类型和成本，被记录下来。
■在研究期间，在1395例(43%F/57%M)患者中发现119例HAIs。医院感染发生率为8.53%。所有ICU患者平均住院时间为4.7±3.1天,HAIs患者为31.85±18.96天。涉及HAIs的最常见的生物体是鲍曼不动杆菌（54.6%），肺炎克雷伯菌(30.3%),大肠杆菌（15.1%），和肠球菌属。（12%）。呼吸机相关性肺炎（VAP）的发病率密度，中线相关血流感染（CLA-BSI），导管相关性尿路感染(CA-UTI)每1000个装置日分别为36.08,17.57和8.86.HAIs的抗生素总费用为105,407欧元。其中,最高的消费成本是碳青霉烯类，其次是粘菌素和卡泊芬金。
■这项研究表明，ICU的医院感染负担很高。为了减轻这种负担，有必要采取更严格的感染预防和控制策略。
■该研究涉及所有确诊HAIs的患者（基于CDC/NHSN病例定义）；在德黑兰一所三级大学医院的普通ICU中，从2020年4月到2021年3月。病人的信息，包括住院时间,结果,处方抗生素的类型和成本，被记录下来。
■在研究期间，在1395例(43%F/57%M)患者中发现119例HAIs。医院感染发生率为8.53%。所有ICU患者平均住院时间为4.7±3.1天,HAIs患者为31.85±18.96天。涉及HAIs的最常见的生物体是鲍曼不动杆菌（54.6%），肺炎克雷伯菌(30.3%),大肠杆菌（15.1%），和肠球菌属。（12%）。呼吸机相关性肺炎（VAP）的发病率密度，中线相关血流感染（CLA-BSI），导管相关性尿路感染(CA-UTI)每1000个装置日分别为36.08,17.57和8.86.HAIs的抗生素总费用为105,407欧元。其中,最高的消费成本是碳青霉烯类，其次是粘菌素和卡泊芬金。
■这项研究表明，ICU的医院感染负担很高。为了减轻这种负担，有必要采取更严格的感染预防和控制策略。
