UNASSIGNED: The study involved all patients with a confirmed HAIs (based on CDC/NHSN case-definitions); in the general ICU of a tertiary university hospital in Tehran, from April 2020 to March 2021. The patients\' information, including length of hospitalization, outcome, type and cost of prescribed antibiotics, were recorded.
UNASSIGNED: During the study period, 119 HAIs were found in 1395 (43% F / 57% M) patients. The prevalence of nosocomial infections was 8.53%. The mean duration of hospitalization in all ICU patients was 4.7 ± 3.1 days, and 31.85 ± 18.96 days in patients with HAIs. The most common organisms involved in HAIs are Acinetobacter baumannii (54.6%), Klebsiella pneumoniae (30.3%), E. coli (15.1%), and Enterococcus spp. (12%). Incidence density of ventilator-associated pneumonia (VAP), central line-associated bloodstream infection (CLA-BSI), and catheter-associated urinary tract infection (CA-UTI) per 1000 device-days were 36.08, 17.57, and 8.86, respectively. The total cost of antibiotics for HAIs was € 105,407. Among these, the highest consumption costs were for carbapenems, followed by colistin and caspofungin.
UNASSIGNED: This study showed the high burden of nosocomial infections in ICUs. Strategies for more strict infection prevention and control are necessary to reduce this burden.
■该研究涉及所有确诊HAIs的患者(基于CDC/NHSN病例定义);在德黑兰一所三级大学医院的普通ICU中,从2020年4月到2021年3月。病人的信息,包括住院时间,结果,处方抗生素的类型和成本,被记录下来。
■在研究期间,在1395例(43%F/57%M)患者中发现119例HAIs。医院感染发生率为8.53%。所有ICU患者平均住院时间为4.7±3.1天,HAIs患者为31.85±18.96天。涉及HAIs的最常见的生物体是鲍曼不动杆菌(54.6%),肺炎克雷伯菌(30.3%),大肠杆菌(15.1%),和肠球菌属。(12%)。呼吸机相关性肺炎(VAP)的发病率密度,中线相关血流感染(CLA-BSI),导管相关性尿路感染(CA-UTI)每1000个装置日分别为36.08,17.57和8.86.HAIs的抗生素总费用为105,407欧元。其中,最高的消费成本是碳青霉烯类,其次是粘菌素和卡泊芬金。
■这项研究表明,ICU的医院感染负担很高。为了减轻这种负担,有必要采取更严格的感染预防和控制策略。