PDF(Pubmed)
Abstract：
Drug hypersensitivity reactions are common in children. Risk factors predisposing to IgE-mediated drug allergies and delayed drug reactions are a matter of debate. Gender, age, previous reactions to the same drug or to another drug, reduced drug metabolism, chronic diseases, polypharmacy, drug doses are linked with the onset of hypersensitivity reactions in some children. Novel advances in genetic polymorphisms can rapidly change the approach to the prevention of reactions since gene testing can be a useful screening test for severe cutaneous adverse reactions. Viral infections may act as cofactors in susceptible individuals. Polypharmacy, high doses, repeated doses and parental route of administration are also risk factors. Clinicians should take into account risk factors to allow the risk-benefit balance to be maintained.
摘要：
药物超敏反应在儿童中很常见。诱发IgE介导的药物过敏和延迟药物反应的风险因素是一个争论的问题。性别,年龄,以前对同一药物或另一种药物的反应，减少药物代谢，慢性疾病,多药，在某些儿童中，药物剂量与超敏反应的发生有关。遗传多态性的新进展可以迅速改变预防反应的方法，因为基因检测可以是严重皮肤不良反应的有用筛查测试。病毒感染可作为易感个体的辅因子。多药，高剂量,重复剂量和父母给药途径也是危险因素.临床医生应考虑风险因素，以保持风险收益平衡。
