截短的 tau 干扰自噬和内溶酶体途径并导致脂质积累。
关键词: Alzheimer’s disease Autophagy Dementia Endosomes Lysosomes TFEB Tau
Mesh : Autophagy tau Proteins / metabolism genetics Lysosomes / metabolism Humans Neurons / metabolism Animals Endosomes / metabolism Lipid Metabolism Tauopathies / metabolism pathology Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism genetics Mice
来 源:
DOI:10.1007/s00018-024-05337-6
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