PDF(Pubmed)
Abstract：
Strongyloidiasis is a helminth infection where symptoms vary, and asymptomatic presentation is common. Chronic strongyloidiasis can cause a high mortality \'hyper-infection\' in immunocompromised states. Understanding at risk populations and symptomology can guide screening and early treatment to reduce hyper-infection risk. A systematic review of studies describing patients in the UK with strongyloidiasis pooled a total of 1,308 patients. Weighted pooled prevalence (WPP) of asymptomatic cases was 27.7% (95% CI 17.1-39.5%, I2 = 92%, p < 0.01). At-risk populations included migrants, returning travellers and armed forces personnel. The most common symptoms reported were abdominal pain (WPP 32.1% (95% CI 20.5-44.8%), I2 = 93%, p < 0.01), rashes (WPP 38.4% (95% CI 13.1-67.7%), I2 = 99%, p < 0.01) and diarrhoea (WPP 12.6% (95% CI 6.7-19.9%), I2=70%, p = 0.03). Symptomatology varied with cohort characteristics. Although asymptomatic presentation is common, patients may present with abdominal pain, diarrhoea or rashes. A low threshold for screening symptomatic individuals in at-risk groups is required.
摘要：
Strongyionasis是一种蠕虫感染，症状各不相同，无症状表现很常见。慢性圆线虫病可在免疫功能低下状态下引起高死亡率“过度感染”。了解高危人群和症状可以指导筛查和早期治疗，以降低过度感染风险。对描述英国线虫病患者的研究进行了系统回顾，共1308例患者。无症状病例的加权合并患病率（WPP）为27.7%（95CI17.1-39.5%，I2=92%，p<0.01]。风险人群包括移民，返回的旅行者和武装强迫人员。最常见的症状是腹痛（WPP32.1%，[95CI20.5-44.8%]，I2=93%，p<0.01),皮疹（WPP38.4%，[95CI13.1-67.7%]，I2=99%，p<0.01）和腹泻（WPP12.6%[95CI6.7-19.9%]，I2=70%，p=0.03)。症状学因队列特征而异。尽管无症状表现很常见，患者可能会出现腹痛，腹泻,或皮疹。在高危人群中筛查有症状的个体需要一个低阈值。
