Abstract：
China\'s Northern and Southern Dynasties period (3rd-6th centuries AD) marked a significant era of ethnic integration in northern China. However, previous ancient DNA studies have primarily focused on northern ethnic groups, with limited research on the genetic formation of the hereditary elite family, especially considering their abundant archaeological record and clear material identity. In this study, we obtained the ancient genome of a hereditary elite family, Gao Bin (, 503-572 AD), at 0.6473-fold coverage with 475132 single-nucleotide polymorphisms (SNPs) on the 1240k panel. His mitochondrial haplogroup belonged to Z4 and Y-haplogroup to O1a1a2b-F2444*. The genetic profile of Gao Bin was most similar to that of the northern Han Chinese. He could be modelled as deriving all his ancestry from Late Neolithic to Iron Age Yellow River farmers without influence from Northeast Asia, Korea, or the Mongolian Plateau. Our study sheds light on the genetic formation of hereditary elite families in the context of the Southern and Northern Dynasties ethnic integration.
摘要：
中国南北朝时期（公元3-6世纪）标志着中国北方民族融合的重要时代。然而,以前的古代DNA研究主要集中在北方民族，由于对遗传性精英家族遗传形成的研究有限，特别是考虑到他们丰富的考古记录和清晰的物质身份。在这项研究中,我们获得了一个遗传性精英家庭的古老基因组，高斌(,503-572AD)，在1240k面板上覆盖0.6473倍，具有475132个单核苷酸多态性（SNP）。他的线粒体单倍群属于Z4，Y-单倍群属于O1a1a2b-F2444*。高斌的遗传特征与北方汉族最为相似。他可以被建模为从新石器时代晚期到铁器时代的黄河农民的所有祖先，而不受东北亚的影响，韩国,或者蒙古高原。我们的研究揭示了南北朝种族融合背景下遗传性精英家庭的遗传形成。
