Abstract：
OBJECTIVE: This study aimed to determine the effect of Photobiomodulation therapy (PBMT) in the treatment of recurrent herpes labialis (RHL), one of the most common herpes simplex virus type 1 infections.
METHODS: In this randomized double blind controlled trial, Twenty-two symptomatic patients with RHL were enrolled. The patients were randomly allocated into one group (5 % acyclovir cream with 940±10 nm wavelength and 4 J/cm2 energy density and 100 mW output power) and another group (5 % Acyclovir 5 times/5 days and sham laser). Lesion size, and pain intensity were considered as the outcome at baseline, 1st 2nd and 3rd days postoperatively.
RESULTS: Pain intensity in PBM + Acyclovir group was significantly lower than Acyclovir without PBM group in both two and three days after intervention (p < 0.001). The lesion size in case group was significantly lower on 7 and 10 days (p < 0.05). Patients in the treatment group were significantly more satisfied with their treatment process (p = 0.008).
CONCLUSIONS: PBMT can be used as an adjuvant tool to acyclovir cream, due to higher potential in reducing postoperative pain, lesion size and also patients satisfaction.
METHODS: In this randomized double blind controlled trial, Twenty-two symptomatic patients with RHL were enrolled. The patients were randomly allocated into one group (5 % acyclovir cream with 940±10 nm wavelength and 4 J/cm2 energy density and 100 mW output power) and another group (5 % Acyclovir 5 times/5 days and sham laser). Lesion size, and pain intensity were considered as the outcome at baseline, 1st 2nd and 3rd days postoperatively.
RESULTS: Pain intensity in PBM + Acyclovir group was significantly lower than Acyclovir without PBM group in both two and three days after intervention (p < 0.001). The lesion size in case group was significantly lower on 7 and 10 days (p < 0.05). Patients in the treatment group were significantly more satisfied with their treatment process (p = 0.008).
CONCLUSIONS: PBMT can be used as an adjuvant tool to acyclovir cream, due to higher potential in reducing postoperative pain, lesion size and also patients satisfaction.
摘要：
目的：本研究旨在确定光生物调节疗法（PBMT）治疗复发性唇疱疹（RHL）的效果，一种最常见的单纯疱疹病毒1型感染。
方法：在这项随机双盲对照试验中，纳入22例有症状的RHL患者。将患者随机分为一组（5％阿昔洛韦乳膏，波长为940±10nm，能量密度为4J/cm2，输出功率为100mW）和另一组（5％阿昔洛韦5次/5天和假激光）。病变大小,和疼痛强度被认为是基线时的结果，术后第2天和第3天。
结果：在干预后2天和3天，PBM+阿昔洛韦组的疼痛强度明显低于无PBM的阿昔洛韦组（p<0.001）。病例组病灶大小在第7天和第10天显著减小(p<0.05)。治疗组患者对其治疗过程的满意度明显更高（p=0.008）。
结论：PBMT可用作阿昔洛韦乳膏的辅助工具，由于减少术后疼痛的潜力更大，病变大小和患者满意度。
方法：在这项随机双盲对照试验中，纳入22例有症状的RHL患者。将患者随机分为一组（5％阿昔洛韦乳膏，波长为940±10nm，能量密度为4J/cm2，输出功率为100mW）和另一组（5％阿昔洛韦5次/5天和假激光）。病变大小,和疼痛强度被认为是基线时的结果，术后第2天和第3天。
结果：在干预后2天和3天，PBM+阿昔洛韦组的疼痛强度明显低于无PBM的阿昔洛韦组（p<0.001）。病例组病灶大小在第7天和第10天显著减小(p<0.05)。治疗组患者对其治疗过程的满意度明显更高（p=0.008）。
结论：PBMT可用作阿昔洛韦乳膏的辅助工具，由于减少术后疼痛的潜力更大，病变大小和患者满意度。
