A systematic review of three databases yielded 24 reports containing 110 cases of patients ≥18 years old with unilateral amblyopia and vision-limiting fellow eye pathology.
Our analysis revealed that 25 of 42 of adult patients (59.5%) gained ≥2 logMAR lines in the amblyopic eye after fellow eye vision loss. The degree of improvement is clinically meaningful (median, 2.6 logMAR lines). Recovery occurs within 12 months of initial loss of fellow eye vision. Regression analysis demonstrated that younger age, worse baseline visual acuity in the amblyopic eye, and worse vision in the fellow eye independently conferred greater gains in amblyopic eye visual acuity. Recovery occurs across amblyopia types and fellow eye pathologies, although disease entities affecting fellow eye retinal ganglion cells demonstrate shorter latencies to recovery.
Amblyopia recovery after fellow eye injury demonstrates that the adult brain harbors the neuroplastic capacity for clinically meaningful recovery, which could potentially be harnessed by novel approaches to treat adults with amblyopia.
方法:对三个数据库的系统评价产生了24例报告,其中包括110例年龄≥18岁的单侧弱视和视力限制的同眼病理患者。
结果:我们的分析显示,42例成年患者中有25例(59.5%)在弱视患者视力下降后,弱视眼增加了≥2条logMAR线。改善程度具有临床意义(中位数,2.6logMAR线)。恢复发生在最初丧失视力的12个月内。回归分析表明,年龄较小,弱视眼的基线视力较差,而同眼视力较差则独立地带来了弱视眼视力的更大增益。恢复发生在弱视类型和其他眼病中,尽管影响同眼视网膜神经节细胞的疾病实体显示恢复潜伏期较短。
结论:眼睛损伤后弱视的恢复表明,成人大脑具有临床上有意义的恢复的神经可塑性,这可能是利用新的方法来治疗成人弱视。