Abstract：
OBJECTIVE: The eccentric implantation of pregnancies in the upper lateral aspect of the uterine cavity is poorly defined clinically. The aim of the current study was to investigate whether differentiating between uterine anomalies that can lead to cavitary distortion has implications for the management of these pregnancies.
METHODS: Eight cases of first-trimester eccentric pregnancy implantation within the endometrial cavity (study group) were retrospectively identified. For each woman in the study group, 10 women identified as having a first-trimester concentric pregnancy implantation during the first-trimester US examination were retrieved from our database (control group). After delivery or pregnancy demise, the presence of uterine anomalies was assessed by a 3D-US examination in all patients.
RESULTS: In the study group patients, an increased incidence of uterine anomalies (50.0% vs. 8.8%, p = 0.007) was found, compared to the controls. In the study group, the eccentric location persisted in half of the pregnancies (n = 4; 50%), whereas the other half migrated to a more centric location within the endometrial cavity (n = 4; 50%). The follow-up examination showed that all the early pregnancy demises occurred in cases where the pregnancy persisted at the eccentric location. Uterine malformations were also detected in all these cases.
CONCLUSIONS: The data point to a significantly higher incidence of uterine anomalies in patients diagnosed with eccentric pregnancy implantation within the endometrial cavity. These results advocate for the value of differentiating between eccentric pregnancies in non-anomalous versus anomalous uteri.
METHODS: Eight cases of first-trimester eccentric pregnancy implantation within the endometrial cavity (study group) were retrospectively identified. For each woman in the study group, 10 women identified as having a first-trimester concentric pregnancy implantation during the first-trimester US examination were retrieved from our database (control group). After delivery or pregnancy demise, the presence of uterine anomalies was assessed by a 3D-US examination in all patients.
RESULTS: In the study group patients, an increased incidence of uterine anomalies (50.0% vs. 8.8%, p = 0.007) was found, compared to the controls. In the study group, the eccentric location persisted in half of the pregnancies (n = 4; 50%), whereas the other half migrated to a more centric location within the endometrial cavity (n = 4; 50%). The follow-up examination showed that all the early pregnancy demises occurred in cases where the pregnancy persisted at the eccentric location. Uterine malformations were also detected in all these cases.
CONCLUSIONS: The data point to a significantly higher incidence of uterine anomalies in patients diagnosed with eccentric pregnancy implantation within the endometrial cavity. These results advocate for the value of differentiating between eccentric pregnancies in non-anomalous versus anomalous uteri.
摘要：
目的：子宫腔上外侧偏心着床的临床定义不明确。本研究的目的是调查区分可能导致空洞变形的子宫异常是否对这些妊娠的管理有影响。
方法：回顾性分析8例早孕期偏心性妊娠子宫内膜腔内植入（研究组）。对于研究组中的每个女性，从我们的数据库（对照组）中检索到10名在美国妊娠早期检查期间被确定为妊娠早期同心植入的妇女。分娩或妊娠死亡后，通过3D-US检查对所有患者的子宫异常进行评估.
结果：在研究组患者中，子宫异常的发生率增加(50.0%vs.8.8%,p=0.007)被发现，与对照组相比。在研究小组中,偏心位置持续在一半的怀孕（n=4;50％），而另一半迁移到子宫内膜腔内更中心的位置（n=4;50％）。随访检查显示，所有早期妊娠死亡都发生在妊娠持续在偏心位置的情况下。在所有这些病例中也检测到子宫畸形。
结论：数据表明，在诊断为子宫内膜腔内偏心妊娠植入的患者中，子宫异常的发生率明显更高。这些结果主张区分非异常子宫和异常子宫中的偏心妊娠的价值。
方法：回顾性分析8例早孕期偏心性妊娠子宫内膜腔内植入（研究组）。对于研究组中的每个女性，从我们的数据库（对照组）中检索到10名在美国妊娠早期检查期间被确定为妊娠早期同心植入的妇女。分娩或妊娠死亡后，通过3D-US检查对所有患者的子宫异常进行评估.
结果：在研究组患者中，子宫异常的发生率增加(50.0%vs.8.8%,p=0.007)被发现，与对照组相比。在研究小组中,偏心位置持续在一半的怀孕（n=4;50％），而另一半迁移到子宫内膜腔内更中心的位置（n=4;50％）。随访检查显示，所有早期妊娠死亡都发生在妊娠持续在偏心位置的情况下。在所有这些病例中也检测到子宫畸形。
结论：数据表明，在诊断为子宫内膜腔内偏心妊娠植入的患者中，子宫异常的发生率明显更高。这些结果主张区分非异常子宫和异常子宫中的偏心妊娠的价值。
