Abstract：
Diabetic wound is one of the most challenge in healthcare, requiring innovative approaches to promote efficient healing. In recent years, lipid nanoparticle-based drug delivery systems have emerged as a promising strategy for enhancing diabetic wound repair by stimulating angiogenesis. These nanoparticles offer unique advantages, including improved drug stability, targeted delivery, and controlled release, making them promising in enhancing the formation of new blood vessels. In this review, we summarize the emerging advances in the utilization of lipid nanoparticles to deliver angiogenic agents and promote angiogenesis in diabetic wounds. Furthermore, we provide an in-depth exploration of key aspects, including the intricate design and fabrication of lipid nanoparticles, their underlying mechanisms of action, and a comprehensive overview of preclinical studies. Moreover, we address crucial considerations pertaining to safety and the translation of these innovative systems into clinical practice. By synthesizing and analyzing the available knowledge, our review offers valuable insights into the future prospects and challenges associated with utilizing the potential of lipid nanoparticle-based drug delivery systems for promoting robust angiogenesis in the intricate process of diabetic wound healing.
摘要：
糖尿病伤口是医疗保健领域最具挑战性的问题之一,需要创新的方法来促进有效的愈合。近年来,基于脂质纳米颗粒的药物递送系统已成为通过刺激血管生成来增强糖尿病伤口修复的有希望的策略.这些纳米粒子提供了独特的优势，包括改善药物稳定性，有针对性的交付，和受控释放，使它们有希望增强新血管的形成。在这次审查中,我们总结了利用脂质纳米粒递送血管生成剂和促进糖尿病伤口血管生成的最新进展。此外，我们对关键方面进行了深入的探索，包括复杂的脂质纳米颗粒的设计和制造，他们潜在的行动机制，以及临床前研究的全面概述。此外，我们讨论了与安全性相关的关键考虑因素，以及将这些创新系统转化为临床实践。通过综合和分析现有的知识，我们的综述提供了对未来前景和挑战的有价值的见解，这些前景和挑战与利用基于脂质纳米颗粒的药物递送系统在糖尿病伤口愈合的复杂过程中促进强大的血管生成的潜力有关。
