Abstract：
UNASSIGNED: The main purpose of the present study was to evaluate the therapeutic efficacy of Aloe vera-coated curcumin encapsulated nanoparticles in mitigating Alzheimer\'s disease progression in mice, by examining behavioural changes, biochemical markers, and histopathological alterations, thus elucidating its potential as a treatment strategy.
UNASSIGNED: The green synthesis method was used to synthesise this nanoformulation, which was then characterised using a variety of techniques, including percentage encapsulation efficacy, UV-visible spectroscopy, DLS, FT-IR, FESEM, and EDX. Several in-vivo assessments, including behavioural evaluations, dose optimisation studies, oxidative stress marker estimation, and histological studies, were conducted to determine the potential therapeutic impact of nanoformulation on the Alzheimer-induced mice model.
UNASSIGNED: The synthesised nanoparticles show a mean diameter of 76.12 nm ±1.23, a PDI of 0.313 ± 0.02, a zeta potential of 6.27 ± 0.65 mV, and the percentage encapsulation efficiency between 90% and 95% indicating good stability of synthesised nanoformulation. With the help of Morris water maze, Y-maze, and novel object recognition assay, the learning capacity and memory were assessed, and the results show that the synthesised nanoformulation significantly decreased the transfer latency to reach baited arm or to the hidden platform within 7 days.
UNASSIGNED: The formulation demonstrated significant biochemical benefits and remarkable cognitive advantages, establishing it as a prospective therapeutic intervention option that is both safe and effective.
UNASSIGNED: The green synthesis method was used to synthesise this nanoformulation, which was then characterised using a variety of techniques, including percentage encapsulation efficacy, UV-visible spectroscopy, DLS, FT-IR, FESEM, and EDX. Several in-vivo assessments, including behavioural evaluations, dose optimisation studies, oxidative stress marker estimation, and histological studies, were conducted to determine the potential therapeutic impact of nanoformulation on the Alzheimer-induced mice model.
UNASSIGNED: The synthesised nanoparticles show a mean diameter of 76.12 nm ±1.23, a PDI of 0.313 ± 0.02, a zeta potential of 6.27 ± 0.65 mV, and the percentage encapsulation efficiency between 90% and 95% indicating good stability of synthesised nanoformulation. With the help of Morris water maze, Y-maze, and novel object recognition assay, the learning capacity and memory were assessed, and the results show that the synthesised nanoformulation significantly decreased the transfer latency to reach baited arm or to the hidden platform within 7 days.
UNASSIGNED: The formulation demonstrated significant biochemical benefits and remarkable cognitive advantages, establishing it as a prospective therapeutic intervention option that is both safe and effective.
摘要：
■本研究的主要目的是评估库拉索芦荟包裹的姜黄素纳米颗粒在减轻小鼠阿尔茨海默病进展中的治疗功效，通过检查行为变化，生化标志物,和组织病理学改变，从而阐明其作为治疗策略的潜力。
■绿色合成方法用于合成这种纳米制剂，然后使用各种技术来表征，包括包封功效百分比，紫外可见光谱，DLS,FT-IR,FESEM，EDX一些体内评估，包括行为评估，剂量优化研究，氧化应激标记估计，和组织学研究，进行以确定纳米制剂对阿尔茨海默诱导的小鼠模型的潜在治疗影响。
■合成的纳米颗粒的平均直径为76.12nm±1.23，PDI为0.313±0.02，ζ电位为6.27±0.65mV，以及在90%和95%之间的百分比包封效率表明合成的纳米制剂的良好稳定性。在莫里斯水迷宫的帮助下，Y-迷宫,和新颖的物体识别试验，评估了学习能力和记忆力，结果表明，合成的纳米制剂可显着降低7天内到达诱饵臂或隐藏平台的转移潜伏期。
■该配方显示出显着的生化益处和显着的认知优势，将其确立为安全有效的前瞻性治疗干预选择。
■绿色合成方法用于合成这种纳米制剂，然后使用各种技术来表征，包括包封功效百分比，紫外可见光谱，DLS,FT-IR,FESEM，EDX一些体内评估，包括行为评估，剂量优化研究，氧化应激标记估计，和组织学研究，进行以确定纳米制剂对阿尔茨海默诱导的小鼠模型的潜在治疗影响。
■合成的纳米颗粒的平均直径为76.12nm±1.23，PDI为0.313±0.02，ζ电位为6.27±0.65mV，以及在90%和95%之间的百分比包封效率表明合成的纳米制剂的良好稳定性。在莫里斯水迷宫的帮助下，Y-迷宫,和新颖的物体识别试验，评估了学习能力和记忆力，结果表明，合成的纳米制剂可显着降低7天内到达诱饵臂或隐藏平台的转移潜伏期。
■该配方显示出显着的生化益处和显着的认知优势，将其确立为安全有效的前瞻性治疗干预选择。
