Abstract：
Pityriasis Rubra Pilaris is a rare, chronic inflammatory dermatosis of unknown etiology, presenting with erythema and papular eruptions. Treatment is difficult due to the lack of causal therapy, guidelines and requires an individualized approach. The most common treatments are systemic retinoids, immunosuppressants, phototherapy and biological therapy. This article presents the case of a 73-year-old man suffering from type 1 pityriasis rubra pilaris. The patient was initially treated with acitretin, which was discontinued due to hypogammaglobulinemia. This rare side effect of acitretin has not been previously published. As a second-line treatment, the patient received methotrexate, but with no clinical improvement after 3 months and an increase in skin pruritus. Finally, the use of isotretinoin resulted in significant clinical improvement and was well tolerated.
摘要：
RubraPilaris是一种罕见的，病因不明的慢性炎症性皮肤病，表现为红斑和丘疹。由于缺乏因果治疗，治疗很困难，指导方针，并需要个性化的方法。最常见的治疗方法是全身性类维生素A，免疫抑制剂,光疗和生物治疗。本文介绍了一名73岁的男子患有1型发红糠疹的病例。患者最初用阿维A治疗，由于低丙种球蛋白血症而停药。阿维A这种罕见的副作用以前尚未发表。作为二线治疗，病人接受了甲氨蝶呤,但3个月后没有临床改善，皮肤瘙痒增加。最后,使用异维A酸可显著改善临床症状,且耐受性良好.
