PDF(Pubmed)
Abstract：
Pancreaticobiliary cancer, encompassing malignancies of both the pancreatic and biliary tract, presents a formidable clinical challenge marked by a uniformly bleak prognosis. The asymptomatic nature of its early stages often leads to delayed detection, contributing to an unfavorable 5-year overall survival rate. Conventional treatment modalities have shown limited efficacy, underscoring the urgent need for alternative therapeutic approaches. In recent years, immunotherapy has emerged as a promising avenue in the fight against pancreaticobiliary cancer. Strategies such as therapeutic vaccines and the use of tumor-infiltrating lymphocytes have garnered attention for their potential to elicit more robust and durable responses. This review seeks to illuminate the landscape of emerging immunotherapeutic interventions, offering insights from both clinical and research perspectives. By deepening our understanding of pancreaticobiliary cancer and exploring innovative treatment modalities, we aim to catalyze improvements in patient outcomes and quality of life.
摘要：
胰胆管癌,包括胰腺和胆道的恶性肿瘤，提出了一个可怕的临床挑战，其特征是一致的预后暗淡。其早期阶段的无症状性质通常导致延迟检测，导致不利的5年总生存率。传统的治疗方式显示出有限的疗效，强调迫切需要替代治疗方法。近年来,免疫疗法已成为对抗胰胆管癌的一个有希望的途径。诸如治疗性疫苗和肿瘤浸润性淋巴细胞的使用等策略因其引起更稳健和持久反应的潜力而引起关注。这篇综述旨在阐明新兴的免疫治疗干预措施的前景，提供从临床和研究角度的见解。通过加深对胰胆管癌的认识，探索创新的治疗方式，我们的目标是促进改善患者预后和生活质量.
