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Abstract：
UNASSIGNED: This Danish cohort study aims to (1) compare patterns of care (POC) and survival of patients with multifocal glioblastoma (mGBM) to those with unifocal glioblastoma (uGBM), and (2) explore the association of patient-related factors with treatment assignment and prognosis, respectively, in the subgroup of mGBM patients.
UNASSIGNED: Data on all adults with newly diagnosed, pathology-confirmed GBM between 2015 and 2019 were extracted from the Danish Neuro-Oncology Registry. To compare POC and survival of mGBM to uGBM, we applied multivariable logistic and Cox regression analysis, respectively. To analyze the association of patient-related factors with treatment assignment and prognosis, we established multivariable logistic and Cox regression models, respectively.
UNASSIGNED: In this cohort of 1343 patients, 231 had mGBM. Of those, 42% underwent tumor resection and 41% were assigned to long-course chemoradiotherapy. Compared to uGBM, mGBM patients less often underwent a partial (odds ratio [OR] 0.4, 95% confidence interval [CI] 0.2-0.6), near-total (OR 0.1, 95% CI 0.07-0.2), and complete resection (OR 0.1, 95% CI 0.07-0.2) versus biopsy. mGBM patients were furthermore less often assigned to long-course chemoradiotherapy (OR 0.6, 95% CI 0.4-0.97). Median overall survival was 7.0 (95% CI 5.7-8.3) months for mGBM patients, and multifocality was an independent poor prognostic factor for survival (hazard ratio 1.3, 95% CI 1.1-1.5). In mGBM patients, initial performance, O[6]-methylguanine-DNA methyltransferase promotor methylation status, and extent of resection were significantly associated with survival.
UNASSIGNED: Patients with mGBM were treated with an overall less intensive approach. Multifocality was a poor prognostic factor for survival with a moderate effect. Prognostic factors for patients with mGBM were identified.
UNASSIGNED: Data on all adults with newly diagnosed, pathology-confirmed GBM between 2015 and 2019 were extracted from the Danish Neuro-Oncology Registry. To compare POC and survival of mGBM to uGBM, we applied multivariable logistic and Cox regression analysis, respectively. To analyze the association of patient-related factors with treatment assignment and prognosis, we established multivariable logistic and Cox regression models, respectively.
UNASSIGNED: In this cohort of 1343 patients, 231 had mGBM. Of those, 42% underwent tumor resection and 41% were assigned to long-course chemoradiotherapy. Compared to uGBM, mGBM patients less often underwent a partial (odds ratio [OR] 0.4, 95% confidence interval [CI] 0.2-0.6), near-total (OR 0.1, 95% CI 0.07-0.2), and complete resection (OR 0.1, 95% CI 0.07-0.2) versus biopsy. mGBM patients were furthermore less often assigned to long-course chemoradiotherapy (OR 0.6, 95% CI 0.4-0.97). Median overall survival was 7.0 (95% CI 5.7-8.3) months for mGBM patients, and multifocality was an independent poor prognostic factor for survival (hazard ratio 1.3, 95% CI 1.1-1.5). In mGBM patients, initial performance, O[6]-methylguanine-DNA methyltransferase promotor methylation status, and extent of resection were significantly associated with survival.
UNASSIGNED: Patients with mGBM were treated with an overall less intensive approach. Multifocality was a poor prognostic factor for survival with a moderate effect. Prognostic factors for patients with mGBM were identified.
摘要：
■这项丹麦队列研究旨在（1）比较多灶性胶质母细胞瘤（mGBM）患者与单灶性胶质母细胞瘤（uGBM）患者的护理模式（POC）和生存率，（2）探讨患者相关因素与治疗分配和预后的关系，分别,在mGBM患者亚组中。
■所有新诊断的成年人的数据，2015年至2019年间病理证实的GBM从丹麦神经肿瘤登记处提取。为了比较mGBM和uGBM的POC和存活率，我们应用多变量logistic和Cox回归分析，分别。分析患者相关因素与治疗分配和预后的关系。我们建立了多变量Logistic和Cox回归模型，分别。
■在这个1343名患者的队列中，231有mGBM。其中,42%接受了肿瘤切除，41%接受了长期放化疗。与UGBM相比，mGBM患者较少接受部分(比值比[OR]0.4，95%置信区间[CI]0.2-0.6)，接近总量（OR0.1，95%CI0.07-0.2），与活检相比，完全切除（OR0.1，95％CI0.07-0.2）。此外,mGBM患者接受长期放化疗的频率较低(OR0.6,95%CI0.4-0.97).mGBM患者的中位总生存期为7.0个月（95％CI5.7-8.3），多灶性是生存的独立不良预后因素(风险比1.3,95%CI1.1-1.5)。在mGBM患者中，初始性能，O[6]-甲基鸟嘌呤-DNA甲基转移酶启动子甲基化状态，切除程度与生存率显著相关。
■mGBM患者采用总体不太密集的方法进行治疗。多病灶是生存的不良预后因素，效果中等。确定了mGBM患者的预后因素。
■所有新诊断的成年人的数据，2015年至2019年间病理证实的GBM从丹麦神经肿瘤登记处提取。为了比较mGBM和uGBM的POC和存活率，我们应用多变量logistic和Cox回归分析，分别。分析患者相关因素与治疗分配和预后的关系。我们建立了多变量Logistic和Cox回归模型，分别。
■在这个1343名患者的队列中，231有mGBM。其中,42%接受了肿瘤切除，41%接受了长期放化疗。与UGBM相比，mGBM患者较少接受部分(比值比[OR]0.4，95%置信区间[CI]0.2-0.6)，接近总量（OR0.1，95%CI0.07-0.2），与活检相比，完全切除（OR0.1，95％CI0.07-0.2）。此外,mGBM患者接受长期放化疗的频率较低(OR0.6,95%CI0.4-0.97).mGBM患者的中位总生存期为7.0个月（95％CI5.7-8.3），多灶性是生存的独立不良预后因素(风险比1.3,95%CI1.1-1.5)。在mGBM患者中，初始性能，O[6]-甲基鸟嘌呤-DNA甲基转移酶启动子甲基化状态，切除程度与生存率显著相关。
■mGBM患者采用总体不太密集的方法进行治疗。多病灶是生存的不良预后因素，效果中等。确定了mGBM患者的预后因素。
