UNASSIGNED: Data on all adults with newly diagnosed, pathology-confirmed GBM between 2015 and 2019 were extracted from the Danish Neuro-Oncology Registry. To compare POC and survival of mGBM to uGBM, we applied multivariable logistic and Cox regression analysis, respectively. To analyze the association of patient-related factors with treatment assignment and prognosis, we established multivariable logistic and Cox regression models, respectively.
UNASSIGNED: In this cohort of 1343 patients, 231 had mGBM. Of those, 42% underwent tumor resection and 41% were assigned to long-course chemoradiotherapy. Compared to uGBM, mGBM patients less often underwent a partial (odds ratio [OR] 0.4, 95% confidence interval [CI] 0.2-0.6), near-total (OR 0.1, 95% CI 0.07-0.2), and complete resection (OR 0.1, 95% CI 0.07-0.2) versus biopsy. mGBM patients were furthermore less often assigned to long-course chemoradiotherapy (OR 0.6, 95% CI 0.4-0.97). Median overall survival was 7.0 (95% CI 5.7-8.3) months for mGBM patients, and multifocality was an independent poor prognostic factor for survival (hazard ratio 1.3, 95% CI 1.1-1.5). In mGBM patients, initial performance, O[6]-methylguanine-DNA methyltransferase promotor methylation status, and extent of resection were significantly associated with survival.
UNASSIGNED: Patients with mGBM were treated with an overall less intensive approach. Multifocality was a poor prognostic factor for survival with a moderate effect. Prognostic factors for patients with mGBM were identified.
■所有新诊断的成年人的数据,2015年至2019年间病理证实的GBM从丹麦神经肿瘤登记处提取。为了比较mGBM和uGBM的POC和存活率,我们应用多变量logistic和Cox回归分析,分别。分析患者相关因素与治疗分配和预后的关系。我们建立了多变量Logistic和Cox回归模型,分别。
■在这个1343名患者的队列中,231有mGBM。其中,42%接受了肿瘤切除,41%接受了长期放化疗。与UGBM相比,mGBM患者较少接受部分(比值比[OR]0.4,95%置信区间[CI]0.2-0.6),接近总量(OR0.1,95%CI0.07-0.2),与活检相比,完全切除(OR0.1,95%CI0.07-0.2)。此外,mGBM患者接受长期放化疗的频率较低(OR0.6,95%CI0.4-0.97).mGBM患者的中位总生存期为7.0个月(95%CI5.7-8.3),多灶性是生存的独立不良预后因素(风险比1.3,95%CI1.1-1.5)。在mGBM患者中,初始性能,O[6]-甲基鸟嘌呤-DNA甲基转移酶启动子甲基化状态,切除程度与生存率显著相关。
■mGBM患者采用总体不太密集的方法进行治疗。多病灶是生存的不良预后因素,效果中等。确定了mGBM患者的预后因素。