Are Altered Expression of Vascular Endothelial Growth Factor and Placental Growth Factor Associated with Placental Angiogenesis in Recurrent Pregnancy Loss?

复发性妊娠丢失中血管内皮生长因子和胎盘生长因子表达的改变与胎盘血管生成相关吗 ？

• 发表时间: 2024 Jul
• 来源期刊: Indian J Clin Biochem
• DOI: 10.1007/s12291-023-01117-4
• PMID: 39005877
• 文章类型: Journal Article
• 作者列表: Sultana S,Renjini Devi MR,Rathod MK,Reddy PP,Ananthapur V

关键词: Angiogenesis; Gene expression; Placental growth factor; Recurrent pregnancy loss; Vascular endothelial growth factor

Abstract

Angiogenesis is one of the most important steps during pregnancy for placental and fetal development. Based on the hypothesis that vascular insufficiency and altered angiogenesis may lead to early pregnancy loss, the present study was aimed to understand the role of Vascular endothelial growth factor (VEGFA) and Placental growth factor (PLGF) gene expression in placental angiogenesis in the pathogenesis of Recurrent pregnancy loss (RPL). Gene expression analysis of VEGFA and PLGF was carried out in the placental tissue collected from 30 women with recurrent pregnancy loss and compared with the placenta obtained from 16 women with medically terminated pregnancy. The mRNA expression of both VEGFA and PLGF genes were significantly downregulated in the placenta of recurrent pregnancy loss in comparison to the placenta of medically terminated pregnancies. In conclusion the results of the present study suggest that altered expression of VEGFA and PLGF genes in placenta disturb the angiogenesis and contribute to the pathogenesis of recurrent pregnancy loss.

摘要

血管生成是妊娠期间胎盘和胎儿发育最重要的步骤之一。基于血管功能不全和血管生成改变可能导致早期妊娠丢失的假设，本研究旨在了解血管内皮生长因子（VEGFA）和胎盘生长因子（PLGF）基因表达在胎盘血管生成中在复发性妊娠丢失（RPL）发病机制中的作用。在从30例复发性妊娠丢失的妇女收集的胎盘组织中进行VEGFA和PLGF的基因表达分析，并与从16例医学终止妊娠的妇女获得的胎盘进行比较。与医学终止妊娠的胎盘相比，复发性妊娠丢失的胎盘中VEGFA和PLGF基因的mRNA表达均显着下调。总之，本研究的结果表明，胎盘中VEGFA和PLGF基因表达的改变会干扰血管生成，并有助于复发性妊娠丢失的发病机理。