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Abstract：
OBJECTIVE: Our aim in this study is to compare patients with ankylosing spondylitis (AS), a rheumatologic disease that can cause eye involvement and the normal population in terms of orbital Doppler findings, which is an inexpensive and easily applicable method that can be used in early diagnosis and follow-up.
METHODS: The study was planned prospectively. The data of patients with AS were compared to those of age- and gender-matched healthy volunteers. A total of 42 participants, 23 (54.8%) males and 19 (45.2%) females, with a mean age of 42.4±12.6 years were included in the study. In addition to demographic information, such as age and gender, the diameter, peak systolic velocity, end-diastolic velocity, mean velocity, resistive index, pulsatility index, and blood flow volumes of the central retinal artery of the left eye were measured using spectral Doppler ultrasonography.
RESULTS: According to the comparison of the patients with and without AS according to orbital Doppler ultrasonography findings, the mean velocity, resistive index, and volume measurements of the patients with AS were significantly higher than those without AS (p=0.028, p=0.039, and p=0.038, respectively). However, in the subgroup analysis of the AS group, the Doppler findings did not significantly differ between the patients with and without anterior uveitis.
CONCLUSIONS: In the patient group with AS, independent of anterior uveitis (AU), there was a difference in Doppler parameters and therefore in ophthalmic vasculature. In patients with AS, orbital vascularity changes can be detected with orbital Doppler US before clinical signs appear.
METHODS: The study was planned prospectively. The data of patients with AS were compared to those of age- and gender-matched healthy volunteers. A total of 42 participants, 23 (54.8%) males and 19 (45.2%) females, with a mean age of 42.4±12.6 years were included in the study. In addition to demographic information, such as age and gender, the diameter, peak systolic velocity, end-diastolic velocity, mean velocity, resistive index, pulsatility index, and blood flow volumes of the central retinal artery of the left eye were measured using spectral Doppler ultrasonography.
RESULTS: According to the comparison of the patients with and without AS according to orbital Doppler ultrasonography findings, the mean velocity, resistive index, and volume measurements of the patients with AS were significantly higher than those without AS (p=0.028, p=0.039, and p=0.038, respectively). However, in the subgroup analysis of the AS group, the Doppler findings did not significantly differ between the patients with and without anterior uveitis.
CONCLUSIONS: In the patient group with AS, independent of anterior uveitis (AU), there was a difference in Doppler parameters and therefore in ophthalmic vasculature. In patients with AS, orbital vascularity changes can be detected with orbital Doppler US before clinical signs appear.
摘要：
目的：我们的目的是比较强直性脊柱炎（AS）患者，一种风湿性疾病，可以导致眼睛受累，正常人群的眼眶多普勒检查结果，这是一种廉价且易于应用的方法，可用于早期诊断和随访。
方法：这项研究是前瞻性计划的。将AS患者的数据与年龄和性别匹配的健康志愿者的数据进行比较。共有42人参加,男性23人（54.8%），女性19人（45.2%），平均年龄42.4±12.6岁纳入研究.除了人口统计信息，比如年龄和性别，直径，收缩期峰值速度,舒张末期血流速度,平均速度，电阻指数，搏动指数,使用频谱多普勒超声测量左眼视网膜中央动脉的血流量。
结果：根据眼眶多普勒超声检查结果比较有无AS患者，平均速度，电阻指数，AS患者的体积测量值明显高于无AS患者（分别为p=0.028，p=0.039和p=0.038）。然而,在AS组的亚组分析中，有和没有前葡萄膜炎的患者的多普勒检查结果没有显著差异.
结论：在AS患者组中，独立于前葡萄膜炎（AU），多普勒参数存在差异，因此在眼科脉管系统中存在差异。在AS患者中，在临床征象出现之前,可以用眼眶多普勒超声检测眼眶血管的变化.
方法：这项研究是前瞻性计划的。将AS患者的数据与年龄和性别匹配的健康志愿者的数据进行比较。共有42人参加,男性23人（54.8%），女性19人（45.2%），平均年龄42.4±12.6岁纳入研究.除了人口统计信息，比如年龄和性别，直径，收缩期峰值速度,舒张末期血流速度,平均速度，电阻指数，搏动指数,使用频谱多普勒超声测量左眼视网膜中央动脉的血流量。
结果：根据眼眶多普勒超声检查结果比较有无AS患者，平均速度，电阻指数，AS患者的体积测量值明显高于无AS患者（分别为p=0.028，p=0.039和p=0.038）。然而,在AS组的亚组分析中，有和没有前葡萄膜炎的患者的多普勒检查结果没有显著差异.
结论：在AS患者组中，独立于前葡萄膜炎（AU），多普勒参数存在差异，因此在眼科脉管系统中存在差异。在AS患者中，在临床征象出现之前,可以用眼眶多普勒超声检测眼眶血管的变化.
