PDF(Pubmed)
Abstract：
This study assessed the acute and sub-chronic toxicity of Camelina oil, a well-known oil rich in polyunsaturated fatty acids that enhance cellular immunity and human health, in Wistar rats. Wistar rats, 5 per sex per group, were randomly assigned to three groups for acute (14 days) toxicity studies and five groups for sub-chronic (90 days) toxicity studies. In the acute study, Camelina sativa oil was administered orally at a single dose of 5000 mg/kg of body weight (BW). The positive control group received a single dose of 5 000 mg/kg BW Canola oil by gavage. In the sub-chronic study, Groups III-V received 250, 500, and 1 000 mg/kg BW of Camelina oil, while Groups I and II received ultra-pure water and Canola oil at a dose of 500 mg/kg BW, respectively. Throughout the experiment, clinical signs, mortality, and body weight were monitored. At the end of the sub-chronic study, hematological, biochemical, and histopathological investigations were conducted. Administration of Camelina oil and Canola had no significant effect on daily weight gain (P > 0.05) of the test rats. Serum calcium levels decreased while phosphorous levels increased in male rats treated with Camelina oil. Other hematological and biochemical parameters showed no significant differences or dose-response effects between control and seed oil groups in both sexes (P < 0.05). Moreover, in animal necropsy, there were no apparent lesions in the liver, heart, and kidney organs in any of the doses administered. In conclusion, the results suggest that oral administration of Camelina oil is unlikely to be toxic. Therefore, the possibility for the development of future human nutrition should be considered.
摘要：
这项研究评估了卡梅琳娜油的急性和亚慢性毒性，一种富含多不饱和脂肪酸的著名油，可增强细胞免疫力和人体健康，在Wistar大鼠中。Wistar大鼠,每组5个性别，随机分为3组进行急性(14天)毒性研究,5组进行亚慢性(90天)毒性研究.在急性研究中，以5000mg/kg体重(BW)的单剂量口服施用紫花苜蓿油。阳性对照组单剂量5000mg/kgBW菜籽油灌胃。在亚慢性研究中，III-V组接受250、500和1000mg/kgBW的Camelina油，而第一组和第二组接受超纯水和500毫克/千克体重的菜籽油，分别。在整个实验过程中,临床体征,死亡率,监测体重。在亚慢性研究结束时，血液学,生物化学，并进行了组织病理学调查。给药Camelina油和Canola对试验大鼠的日增重没有显着影响（P>0.05）。用Camelina油治疗的雄性大鼠的血清钙水平降低，而磷水平升高。其他血液和生化指标在男女对照组和种子油组之间没有显着差异或剂量-反应效应（P<0.05）。此外，在动物尸检中，肝脏没有明显的病变,心,和任何剂量的肾脏器官。总之,结果表明，口服Camelina油不太可能有毒。因此,应该考虑未来人类营养发展的可能性。
