PDF(Pubmed)
Abstract：
Image-guided thermal ablation (IGTA) is an important treatment modality for interventional oncology. It is widely used for the treatment of solid tumors, such as liver, lung, breast, kidney, and thyroid cancers. IGTA include radiofrequency ablation, microwave ablation (MWA), cryoablation, and laser ablation. Compared with other energy sources, MWA has the advantage of a large ablative volume, short ablative time, and a low heat sink effect. MWA can also induce antitumor immunity; however, only a minority of patients derive a clinical benefit from it. Based on these data, the combination of MWA and immunotherapy has emerged as a promising new direction for cancer treatment. This review article focuses on current research on the combination of MWA and immunotherapy. The status of immune activation and related studies involving MWA for the treatment of various malignant tumors are discussed.
摘要：
图像引导热消融（IGTA）是介入肿瘤学的重要治疗方式。它广泛用于治疗实体瘤，比如肝脏，肺，乳房,肾,和甲状腺癌。IGTA包括射频消融，微波消融（MWA），冷冻消融,和激光烧蚀。与其他能源相比，MWA具有消融体积大的优点，短消融时间,和低散热效果。MWA也可以诱导抗肿瘤免疫；然而，只有少数患者从中获得临床益处。基于这些数据,MWA和免疫治疗的结合已成为癌症治疗的一个有希望的新方向.本文就目前MWA与免疫治疗结合的研究现状作一综述。讨论了免疫激活的状况以及涉及MWA治疗各种恶性肿瘤的相关研究。
