Abstract：
Accurate stratification of an ovarian mucinous neoplasm as primary or secondary is always challenging as they show overlapping histomorphological and immunohistochemical features. Immunohistochemical staining for SATB2 and PAX8 was performed on 80 cases of mucinous ovarian neoplasms subdivided into 53 primary [25 primary ovarian mucinous carcinomas (POMCs) and 28 mucinous borderline tumors (MBTs)] and 27 secondary (12 of colonic origin, 7 of appendiceal origin, and 8 of gastric origin). Expression was correlated with different clinicopathologic parameters. PAX8-positive immunostaining was detected in 38 out of 53 cases (71.69%) of primary ovarian mucinous neoplasms (POMNs) with null positivity in the secondary ovarian mucinous tumors (0/27). SATB2-positive expression was detected in 16 out of 27 cases (59.26%) of the secondary ovarian mucinous tumors. None of the studied POMNs showed any positive immunostaining for SATB2 (0/53). A profile of SATB2-/PAX8+ and SATB2+/PAX8- can be used to differentiate POMNCs from secondary ovarian mucinous tumors of GI origin, respectively, with 100% specificity. PAX8 expression is associated with some clinicopathologic parameters providing the basis for the possible usage of PAX8 as prognostic marker.
摘要：
卵巢粘液性肿瘤作为原发性或继发性的准确分层总是具有挑战性的，因为它们显示出重叠的组织形态学和免疫组织化学特征。对80例粘液性卵巢肿瘤进行了SATB2和PAX8的免疫组织化学染色，分为53例原发性[25例原发性卵巢粘液性癌（POMC）和28例粘液性交界性肿瘤（MBT）]和27例继发性（结肠起源的12例，7阑尾起源，和胃源8）。表达与不同的临床病理参数相关。在53例原发性卵巢粘液性肿瘤（POMNs）中，有38例（71.69％）检测到PAX8阳性免疫染色，在继发性卵巢粘液性肿瘤中无阳性（0/27）。在27例继发性卵巢粘液性肿瘤中，有16例（59.26％）检测到SATB2阳性表达。所研究的POMN均未显示SATB2的任何阳性免疫染色(0/53)。SATB2-/PAX8+和SATB2+/PAX8-的谱可用于区分POMNCs与胃肠道来源的继发性卵巢粘液性肿瘤，分别,具有100%的特异性。PAX8的表达与一些临床病理参数相关，为PAX8可能用作预后标志物提供了基础。
