Abstract：
Periodontal diseases are highly prevalent chronic diseases, and severe periodontitis creates functional and esthetic problems and decreases self-esteem for a large percentage of the older population worldwide. In many cases of periodontitis, there is no distinct tell-tale pain that motivates a patient to seek treatment, rather the signs become clinically detectable late, and typically when the disease has progressed to a problematic level for the life of the dentition. Early periodontal screening and diagnostics tools will provide early recognition of periodontal diseases and facilitate timely management of the disease to reduce tooth loss. To this goal, gingival crevicular fluid is easily sampled, can be repeatedly and non-invasively collected, and can be tested for potential biomarkers. Moreover, the site specificity of periodontal diseases enhances the usefulness of gingival crevicular fluid sampled from specific sites as a biofluid for diagnosis and longitudinal monitoring of periodontal diseases. The present review aimed to provide up-to-date information on potential diagnostic biomarkers with utility that can be assayed from gingival crevicular fluid samples, focusing on what is new and useful and providing only general historic background textually and in a tabulated format.
摘要：
牙周病是一种高度流行的慢性疾病,严重的牙周炎会产生功能和美学问题，并降低全球大部分老年人口的自尊。在许多牙周炎病例中，没有明显的疼痛会促使患者寻求治疗，相反，这些迹象在后期被临床检测到，通常是当疾病在牙列寿命内发展到有问题的水平时。早期牙周筛查和诊断工具将提供牙周疾病的早期识别，并促进疾病的及时管理，以减少牙齿脱落。为了这个目标,龈沟液很容易取样，可以反复和非侵入性地收集，并且可以测试潜在的生物标志物。此外，牙周疾病的部位特异性增强了从特定部位取样的龈沟液作为牙周疾病诊断和纵向监测的生物液的实用性。本综述旨在提供有关潜在诊断生物标志物的最新信息，这些生物标志物具有实用性，可以从牙龈沟液样本中进行测定。专注于什么是新的和有用的，只提供一般的历史背景文本和表格格式。
