METHODS: Subjective measurements of CRS included the Sino-Nasal Outcome Test (SNOT-22) and objective measurements included Lund-MacKay sinus CT score and endoscopic scoring. Outcomes were compared with control subjects with CRS co-presenting with allergies, asthma, or aspirin-exacerbated respiratory disease (AERD).
RESULTS: A total of 62 patients (12 CRS alone, 14 CRS/psoriasis, 12 CRS/AERD, 12 CRS/allergic asthmatic, 12 CRS/non-allergic asthmatic) were included. Comparative analysis utilizing χ2 revealed no significant differences in any factor between CRS/psoriatic patients and all other groups associated with T2 presentations. Specifically, psoriatic patients had comparable reductions in smell, similar complaints of pain/pressure, negligible purulent drainage/crusting, and comparable extent of disease on their CT scan, as well as similar blood eosinophilia. The only significant difference was in lack of productivity (p < 0.05) with trends toward reduced concentration, waking up tired, and lack of sleep parameters presumably related to systemic psoriatic manifestations.
CONCLUSIONS: Despite the increased prevalence of CRS in psoriasis patients, our data suggest that when present, psoriasis does not predict the presence of a T1 process in the sinuses.
方法:CRS的主观测量包括鼻窦结果测试(SNOT-22),客观测量包括Lund-MacKay窦CT评分和内窥镜评分。结果与CRS合并过敏的对照组进行比较,哮喘,或阿司匹林加重呼吸道疾病(AERD)。
结果:总共62例患者(仅12例CRS,14CRS/牛皮癣,12CRS/AERD,12CRS/过敏性哮喘,包括12个CRS/非过敏性哮喘)。使用χ2的比较分析显示,CRS/银屑病患者与所有其他与T2表现相关的组之间在任何因素上都没有显着差异。具体来说,牛皮癣患者有相当的嗅觉减少,类似的疼痛/压力抱怨,可忽略的脓性排水/结皮,和他们的CT扫描上的疾病程度相当,以及类似的嗜酸性粒细胞增多。唯一的显着差异是缺乏生产力(p&lt;0.05)与浓度降低的趋势,醒来累了,和缺乏睡眠参数可能与系统性银屑病表现有关。
结论:尽管银屑病患者的CRS患病率增加,我们的数据表明,当存在时,牛皮癣不能预测鼻窦中T1过程的存在。