Abstract：
The study by Feeney et al. provides critical insights into the prognostic implications of NOTCH pathway activation in adenoid cystic carcinoma (ACC), particularly after disease recurrence. Utilizing both next-generation sequencing and immunohistochemistry, the research delineates the survival outcomes between NOTCH-activated and non-activated ACC groups, highlighting poorer outcomes in the former. The findings advocate for the targeted therapeutic approach and suggest a potential for personalized treatment strategies, emphasizing the need for further research into NOTCH pathway inhibitors and their clinical applications.
摘要：
Feeney等人的研究。提供了关于腺样囊性癌（ACC）NOTCH通路激活的预后意义的重要见解，特别是在疾病复发后。利用下一代测序和免疫组织化学，该研究描述了NOTCH激活和未激活ACC组之间的生存结果，突出前者较差的结果。研究结果倡导有针对性的治疗方法，并提出了个性化治疗策略的潜力，强调需要进一步研究NOTCH途径抑制剂及其临床应用。
