Abstract：
Jointpoint Regression Software from the National Cancer Institute was used to model age-adjusted male and female pleural and peritoneal mesothelioma rates in the surveillance, epidemiology, and end results (SEER) 8, SEER 12, and SEER 22 cancer registries. Linear mixed models were then used to determine if there was a statistical association between U.S. cosmetic talc consumption and the 30-year lagged age-adjusted mesothelioma rates (1) over the reporting period for each registry and (2) for the periods of time identified by the jointpoint model where changes in the rate of mesothelioma occurred. Regardless of the SEER registry used, from the early-1980s through 2020, rates of peritoneal mesothelioma have remained steady or declined. Female pleural mesothelioma rates were unchanged from the early-1980s until 2017 when rates declined, while male rates peaked in the early 1990s and have since declined. Cosmetic talc consumption was not statistically associated with an increased rate of pleural or peritoneal mesothelioma in males or females, suggesting that the use of cosmetic talc products is not associated with the development of mesothelioma.
摘要：
美国国家癌症研究所的Jointpoint回归软件用于模拟年龄调整后的男性和女性胸膜和腹膜间皮瘤发生率，流行病学,以及最终结果(SEER)8、SEER12和SEER22癌症登记处。然后使用线性混合模型来确定美国化妆品滑石粉消费与30年滞后年龄调整的间皮瘤发生率之间是否存在统计关联（1）在每个注册表的报告期内，以及（2）在确定的时间段内间皮瘤发生率发生变化的联合点模型。无论使用何种SEER注册表，从20世纪80年代初到2020年,腹膜间皮瘤的发病率保持稳定或下降.女性胸膜间皮瘤的发病率从20世纪80年代初一直保持不变，直到2017年发病率下降，而男性比率在20世纪90年代初达到顶峰，此后一直在下降。在男性或女性中，化妆品滑石粉的消耗量与胸膜或腹膜间皮瘤的发生率无统计学关联，这表明使用化妆品滑石产品与间皮瘤的发展无关。
